http://www.tkuhn.ch/bel2nanopub/RAiCaff0dBE2s828NXYKrf7RNRdEhZw6a2LlFCx1cuem4#Head http://www.tkuhn.ch/bel2nanopub/RAiCaff0dBE2s828NXYKrf7RNRdEhZw6a2LlFCx1cuem4 http://www.nanopub.org/nschema#hasAssertion http://www.tkuhn.ch/bel2nanopub/RAiCaff0dBE2s828NXYKrf7RNRdEhZw6a2LlFCx1cuem4#assertion http://www.tkuhn.ch/bel2nanopub/RAiCaff0dBE2s828NXYKrf7RNRdEhZw6a2LlFCx1cuem4 http://www.nanopub.org/nschema#hasProvenance http://www.tkuhn.ch/bel2nanopub/RAiCaff0dBE2s828NXYKrf7RNRdEhZw6a2LlFCx1cuem4#provenance http://www.tkuhn.ch/bel2nanopub/RAiCaff0dBE2s828NXYKrf7RNRdEhZw6a2LlFCx1cuem4 http://www.nanopub.org/nschema#hasPublicationInfo http://www.tkuhn.ch/bel2nanopub/RAiCaff0dBE2s828NXYKrf7RNRdEhZw6a2LlFCx1cuem4#pubinfo http://www.tkuhn.ch/bel2nanopub/RAiCaff0dBE2s828NXYKrf7RNRdEhZw6a2LlFCx1cuem4 http://www.w3.org/1999/02/22-rdf-syntax-ns#type http://www.nanopub.org/nschema#Nanopublication http://www.tkuhn.ch/bel2nanopub/RAiCaff0dBE2s828NXYKrf7RNRdEhZw6a2LlFCx1cuem4#assertion http://resource.belframework.org/belframework/1.0/namespace/selventa-named-human-complexes/p85%2Fp110%20PI3Kinase%20Complex http://www.w3.org/1999/02/22-rdf-syntax-ns#type http://amigo.geneontology.org/amigo/term/GO:0043234 http://www.tkuhn.ch/bel2nanopub/RAiCaff0dBE2s828NXYKrf7RNRdEhZw6a2LlFCx1cuem4#_1 http://purl.obolibrary.org/obo/RO_0002204 http://www.genenames.org/cgi-bin/gene_symbol_report?hgnc_id=5464 http://www.tkuhn.ch/bel2nanopub/RAiCaff0dBE2s828NXYKrf7RNRdEhZw6a2LlFCx1cuem4#_1 http://www.w3.org/1999/02/22-rdf-syntax-ns#type http://www.ebi.ac.uk/chebi/searchId.do?chebiId=CHEBI_36080 http://www.tkuhn.ch/bel2nanopub/RAiCaff0dBE2s828NXYKrf7RNRdEhZw6a2LlFCx1cuem4#_2 http://semanticscience.org/resource/SIO_000139 http://resource.belframework.org/belframework/1.0/namespace/selventa-named-human-complexes/p85%2Fp110%20PI3Kinase%20Complex http://www.tkuhn.ch/bel2nanopub/RAiCaff0dBE2s828NXYKrf7RNRdEhZw6a2LlFCx1cuem4#_2 http://www.w3.org/1999/02/22-rdf-syntax-ns#type http://amigo.geneontology.org/amigo/term/GO:0016301 http://www.tkuhn.ch/bel2nanopub/RAiCaff0dBE2s828NXYKrf7RNRdEhZw6a2LlFCx1cuem4#_3 http://purl.obolibrary.org/obo/BFO_0000066 http://purl.bioontology.org/ontology/MSH/D002460 http://www.tkuhn.ch/bel2nanopub/RAiCaff0dBE2s828NXYKrf7RNRdEhZw6a2LlFCx1cuem4#_3 http://purl.obolibrary.org/obo/BFO_0000066 http://purl.bioontology.org/ontology/MSH/D007668 http://www.tkuhn.ch/bel2nanopub/RAiCaff0dBE2s828NXYKrf7RNRdEhZw6a2LlFCx1cuem4#_3 http://purl.obolibrary.org/obo/BFO_0000066 http://www.lgcstandards-atcc.org/Products/All/CRL-2210.aspx http://www.tkuhn.ch/bel2nanopub/RAiCaff0dBE2s828NXYKrf7RNRdEhZw6a2LlFCx1cuem4#_3 http://purl.obolibrary.org/obo/BFO_0000066 http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?id=10116 http://www.tkuhn.ch/bel2nanopub/RAiCaff0dBE2s828NXYKrf7RNRdEhZw6a2LlFCx1cuem4#_3 http://semanticscience.org/resource/SIO_000255 http://www.tkuhn.ch/bel2nanopub/RAiCaff0dBE2s828NXYKrf7RNRdEhZw6a2LlFCx1cuem4#_4 http://www.tkuhn.ch/bel2nanopub/RAiCaff0dBE2s828NXYKrf7RNRdEhZw6a2LlFCx1cuem4#_3 http://www.w3.org/1999/02/22-rdf-syntax-ns#object http://www.tkuhn.ch/bel2nanopub/RAiCaff0dBE2s828NXYKrf7RNRdEhZw6a2LlFCx1cuem4#_2 http://www.tkuhn.ch/bel2nanopub/RAiCaff0dBE2s828NXYKrf7RNRdEhZw6a2LlFCx1cuem4#_3 http://www.w3.org/1999/02/22-rdf-syntax-ns#predicate http://www.selventa.com/vocabulary/increases http://www.tkuhn.ch/bel2nanopub/RAiCaff0dBE2s828NXYKrf7RNRdEhZw6a2LlFCx1cuem4#_3 http://www.w3.org/1999/02/22-rdf-syntax-ns#subject http://www.tkuhn.ch/bel2nanopub/RAiCaff0dBE2s828NXYKrf7RNRdEhZw6a2LlFCx1cuem4#_1 http://www.tkuhn.ch/bel2nanopub/RAiCaff0dBE2s828NXYKrf7RNRdEhZw6a2LlFCx1cuem4#_3 http://www.w3.org/1999/02/22-rdf-syntax-ns#type http://www.w3.org/1999/02/22-rdf-syntax-ns#Statement http://www.tkuhn.ch/bel2nanopub/RAiCaff0dBE2s828NXYKrf7RNRdEhZw6a2LlFCx1cuem4#_4 http://purl.org/dc/terms/subject TextLocation http://www.tkuhn.ch/bel2nanopub/RAiCaff0dBE2s828NXYKrf7RNRdEhZw6a2LlFCx1cuem4#_4 http://www.w3.org/1999/02/22-rdf-syntax-ns#value Results http://www.tkuhn.ch/bel2nanopub/RAiCaff0dBE2s828NXYKrf7RNRdEhZw6a2LlFCx1cuem4#assertion http://www.w3.org/2000/01/rdf-schema#label p(HGNC:IGF1) -> kin(complex(NCH:"p85/p110 PI3Kinase Complex")) http://www.tkuhn.ch/bel2nanopub/RAiCaff0dBE2s828NXYKrf7RNRdEhZw6a2LlFCx1cuem4#provenance http://resource.belframework.org/belframework/1.0/knowledge/small_corpus.bel http://purl.org/dc/elements/1.1/description Approximately 2000 hand curated statements drawn from 57 PubMeds. http://resource.belframework.org/belframework/1.0/knowledge/small_corpus.bel http://purl.org/dc/elements/1.1/rights Copyright (c) 2011-2012, Selventa. All Rights Reserved. http://resource.belframework.org/belframework/1.0/knowledge/small_corpus.bel http://purl.org/dc/elements/1.1/title BEL Framework Small Corpus Document http://resource.belframework.org/belframework/1.0/knowledge/small_corpus.bel http://purl.org/dc/terms/license Creative Commons Attribution-Non-Commercial-ShareAlike 3.0 Unported License http://resource.belframework.org/belframework/1.0/knowledge/small_corpus.bel http://purl.org/pav/authoredBy http://www.tkuhn.ch/bel2nanopub/RAiCaff0dBE2s828NXYKrf7RNRdEhZw6a2LlFCx1cuem4#_6 http://resource.belframework.org/belframework/1.0/knowledge/small_corpus.bel http://purl.org/pav/version 1.6 http://www.tkuhn.ch/bel2nanopub/RAiCaff0dBE2s828NXYKrf7RNRdEhZw6a2LlFCx1cuem4#_5 http://www.w3.org/ns/prov#value PI3K-dependent activation of PKB is an intermediary in the phosphorylation and inactivation of GSK-3 induced by insulin and other growth factors (10, 12, 14). Insulin and IGF-1 efficiently activate the PI3K pathway in NIH 3T3 and Rat1 cells, respectively. GSK-3 phosphorylation induced by insulin and IGF-1 were eliminated by pretreatment with the PI3K inhibitors wortmannin or LY294002. In contrast, the effects of 8-Br-cAMP or forskolin on GSK-3 phosphorylation in these cell lines were not altered by inhibition of PI3K activity with wortmannin or LY294002 (Fig. 2A), excluding the possibility that PKA induces GSK-3 phosphorylation through activation of PI3K. http://www.tkuhn.ch/bel2nanopub/RAiCaff0dBE2s828NXYKrf7RNRdEhZw6a2LlFCx1cuem4#_5 http://www.w3.org/ns/prov#wasQuotedFrom http://www.ncbi.nlm.nih.gov/pubmed/11035810 http://www.tkuhn.ch/bel2nanopub/RAiCaff0dBE2s828NXYKrf7RNRdEhZw6a2LlFCx1cuem4#_6 http://www.w3.org/2000/01/rdf-schema#comment support@belframework.org http://www.tkuhn.ch/bel2nanopub/RAiCaff0dBE2s828NXYKrf7RNRdEhZw6a2LlFCx1cuem4#_6 http://www.w3.org/2000/01/rdf-schema#label Selventa http://www.tkuhn.ch/bel2nanopub/RAiCaff0dBE2s828NXYKrf7RNRdEhZw6a2LlFCx1cuem4#assertion http://www.w3.org/ns/prov#hadPrimarySource http://www.ncbi.nlm.nih.gov/pubmed/11035810 http://www.tkuhn.ch/bel2nanopub/RAiCaff0dBE2s828NXYKrf7RNRdEhZw6a2LlFCx1cuem4#assertion http://www.w3.org/ns/prov#wasDerivedFrom http://resource.belframework.org/belframework/1.0/knowledge/small_corpus.bel http://www.tkuhn.ch/bel2nanopub/RAiCaff0dBE2s828NXYKrf7RNRdEhZw6a2LlFCx1cuem4#assertion http://www.w3.org/ns/prov#wasDerivedFrom http://www.tkuhn.ch/bel2nanopub/RAiCaff0dBE2s828NXYKrf7RNRdEhZw6a2LlFCx1cuem4#_5 http://www.tkuhn.ch/bel2nanopub/RAiCaff0dBE2s828NXYKrf7RNRdEhZw6a2LlFCx1cuem4#pubinfo http://www.tkuhn.ch/bel2nanopub/RAiCaff0dBE2s828NXYKrf7RNRdEhZw6a2LlFCx1cuem4 http://purl.org/dc/terms/created 2014-07-03T14:29:34.673+02:00 http://www.tkuhn.ch/bel2nanopub/RAiCaff0dBE2s828NXYKrf7RNRdEhZw6a2LlFCx1cuem4 http://purl.org/pav/createdBy http://orcid.org/0000-0001-6818-334X http://www.tkuhn.ch/bel2nanopub/RAiCaff0dBE2s828NXYKrf7RNRdEhZw6a2LlFCx1cuem4 http://purl.org/pav/createdBy http://orcid.org/0000-0002-1267-0234