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All rights reserved. http://resource.belframework.org/belframework/1.0/knowledge/large_corpus.bel http://purl.org/dc/elements/1.1/title BEL Framework Large Corpus Document http://resource.belframework.org/belframework/1.0/knowledge/large_corpus.bel http://purl.org/pav/authoredBy http://www.tkuhn.ch/bel2nanopub/RAiHPhj4YdVr_ZxNDUVnOAOyPyQZjGdaIBsx7uvj7QfAQ#_5 http://resource.belframework.org/belframework/1.0/knowledge/large_corpus.bel http://purl.org/pav/version 1.4 http://www.tkuhn.ch/bel2nanopub/RAiHPhj4YdVr_ZxNDUVnOAOyPyQZjGdaIBsx7uvj7QfAQ#_4 http://www.w3.org/ns/prov#value A dominant negative form of ATF6 blocked ER stress induction of both ATF6 site and GRP78 reporter genes. We further found that GAL4-ATF6 could be activated by ER stress. These results demonstrate that ATF6 is a direct target of the ER stress response. A proximal sensor of the ER stress response, human IRE1 (hIRE1), was sufficient to activate the ATF6 reporter gene, while a dominant negative form of hIRE1 blocked ER stress activation, suggesting that hIRE1 is upstream of ATF6 in the ER stress signaling pathway. http://www.tkuhn.ch/bel2nanopub/RAiHPhj4YdVr_ZxNDUVnOAOyPyQZjGdaIBsx7uvj7QfAQ#_4 http://www.w3.org/ns/prov#wasQuotedFrom http://www.ncbi.nlm.nih.gov/pubmed/10856300 http://www.tkuhn.ch/bel2nanopub/RAiHPhj4YdVr_ZxNDUVnOAOyPyQZjGdaIBsx7uvj7QfAQ#_5 http://www.w3.org/2000/01/rdf-schema#label Selventa http://www.tkuhn.ch/bel2nanopub/RAiHPhj4YdVr_ZxNDUVnOAOyPyQZjGdaIBsx7uvj7QfAQ#assertion http://www.w3.org/ns/prov#hadPrimarySource http://www.ncbi.nlm.nih.gov/pubmed/10856300 http://www.tkuhn.ch/bel2nanopub/RAiHPhj4YdVr_ZxNDUVnOAOyPyQZjGdaIBsx7uvj7QfAQ#assertion http://www.w3.org/ns/prov#wasDerivedFrom http://resource.belframework.org/belframework/1.0/knowledge/large_corpus.bel http://www.tkuhn.ch/bel2nanopub/RAiHPhj4YdVr_ZxNDUVnOAOyPyQZjGdaIBsx7uvj7QfAQ#assertion http://www.w3.org/ns/prov#wasDerivedFrom http://www.tkuhn.ch/bel2nanopub/RAiHPhj4YdVr_ZxNDUVnOAOyPyQZjGdaIBsx7uvj7QfAQ#_4 http://www.tkuhn.ch/bel2nanopub/RAiHPhj4YdVr_ZxNDUVnOAOyPyQZjGdaIBsx7uvj7QfAQ#pubinfo http://www.tkuhn.ch/bel2nanopub/RAiHPhj4YdVr_ZxNDUVnOAOyPyQZjGdaIBsx7uvj7QfAQ http://purl.org/dc/terms/created 2014-07-03T14:29:51.318+02:00 http://www.tkuhn.ch/bel2nanopub/RAiHPhj4YdVr_ZxNDUVnOAOyPyQZjGdaIBsx7uvj7QfAQ http://purl.org/pav/createdBy http://orcid.org/0000-0001-6818-334X http://www.tkuhn.ch/bel2nanopub/RAiHPhj4YdVr_ZxNDUVnOAOyPyQZjGdaIBsx7uvj7QfAQ http://purl.org/pav/createdBy http://orcid.org/0000-0002-1267-0234