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All rights reserved. http://resource.belframework.org/belframework/1.0/knowledge/large_corpus.bel http://purl.org/dc/elements/1.1/title BEL Framework Large Corpus Document http://resource.belframework.org/belframework/1.0/knowledge/large_corpus.bel http://purl.org/pav/authoredBy http://www.tkuhn.ch/bel2nanopub/RAiO7-cv0YwWUD7riyEV96z6e0n8FRUbAfItCSExuAkaY#_6 http://resource.belframework.org/belframework/1.0/knowledge/large_corpus.bel http://purl.org/pav/version 1.4 http://www.tkuhn.ch/bel2nanopub/RAiO7-cv0YwWUD7riyEV96z6e0n8FRUbAfItCSExuAkaY#_5 http://www.w3.org/ns/prov#value It is known that Gp96 is released from cells at necrosis induced, for example, by virus infection. Although this event supports the efficient induction of immune responses, it might also interfere with processes that are susceptible to chronic inflammation, such as wound healing after tissue damage. Therefore, Gp96-mediated stimulation of the immune system requires tight regulation. Here we show that human thrombocytes specifically interact with Gp96 and that binding of Gp96 to platelets is enhanced more than 10-fold on activation by thrombin. Gp96 interferes with neither thrombin-induced platelet activation nor platelet aggregation. However, the presence of platelets during Gp96-mediated DC activation reduces the secretion of proinflammatory cytokines and the activation of DCs. http://www.tkuhn.ch/bel2nanopub/RAiO7-cv0YwWUD7riyEV96z6e0n8FRUbAfItCSExuAkaY#_5 http://www.w3.org/ns/prov#wasQuotedFrom http://www.ncbi.nlm.nih.gov/pubmed/11986223 http://www.tkuhn.ch/bel2nanopub/RAiO7-cv0YwWUD7riyEV96z6e0n8FRUbAfItCSExuAkaY#_6 http://www.w3.org/2000/01/rdf-schema#label Selventa http://www.tkuhn.ch/bel2nanopub/RAiO7-cv0YwWUD7riyEV96z6e0n8FRUbAfItCSExuAkaY#assertion http://www.w3.org/ns/prov#hadPrimarySource http://www.ncbi.nlm.nih.gov/pubmed/11986223 http://www.tkuhn.ch/bel2nanopub/RAiO7-cv0YwWUD7riyEV96z6e0n8FRUbAfItCSExuAkaY#assertion http://www.w3.org/ns/prov#wasDerivedFrom http://resource.belframework.org/belframework/1.0/knowledge/large_corpus.bel http://www.tkuhn.ch/bel2nanopub/RAiO7-cv0YwWUD7riyEV96z6e0n8FRUbAfItCSExuAkaY#assertion http://www.w3.org/ns/prov#wasDerivedFrom http://www.tkuhn.ch/bel2nanopub/RAiO7-cv0YwWUD7riyEV96z6e0n8FRUbAfItCSExuAkaY#_5 http://www.tkuhn.ch/bel2nanopub/RAiO7-cv0YwWUD7riyEV96z6e0n8FRUbAfItCSExuAkaY#pubinfo http://www.tkuhn.ch/bel2nanopub/RAiO7-cv0YwWUD7riyEV96z6e0n8FRUbAfItCSExuAkaY http://purl.org/dc/terms/created 2014-07-03T14:30:02.815+02:00 http://www.tkuhn.ch/bel2nanopub/RAiO7-cv0YwWUD7riyEV96z6e0n8FRUbAfItCSExuAkaY http://purl.org/pav/createdBy http://orcid.org/0000-0001-6818-334X http://www.tkuhn.ch/bel2nanopub/RAiO7-cv0YwWUD7riyEV96z6e0n8FRUbAfItCSExuAkaY http://purl.org/pav/createdBy http://orcid.org/0000-0002-1267-0234