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All rights reserved. http://resource.belframework.org/belframework/1.0/knowledge/large_corpus.bel http://purl.org/dc/elements/1.1/title BEL Framework Large Corpus Document http://resource.belframework.org/belframework/1.0/knowledge/large_corpus.bel http://purl.org/pav/authoredBy http://www.tkuhn.ch/bel2nanopub/RAiWyqYH9AcHCUdMEscZUCdgkpRM3l6VSaGw37ZxKrcXs#_5 http://resource.belframework.org/belframework/1.0/knowledge/large_corpus.bel http://purl.org/pav/version 1.4 http://www.tkuhn.ch/bel2nanopub/RAiWyqYH9AcHCUdMEscZUCdgkpRM3l6VSaGw37ZxKrcXs#_3 http://purl.org/dc/elements/1.1/identifier Biochemistry of Lipids, Lipoproteins and Membranes 2002 - Chapter 16 http://www.tkuhn.ch/bel2nanopub/RAiWyqYH9AcHCUdMEscZUCdgkpRM3l6VSaGw37ZxKrcXs#_3 http://purl.org/dc/elements/1.1/title Biochemistry of Lipids, Lipoproteins and Membranes 2002 - Chapter 16 http://www.tkuhn.ch/bel2nanopub/RAiWyqYH9AcHCUdMEscZUCdgkpRM3l6VSaGw37ZxKrcXs#_3 http://purl.org/dc/elements/1.1/type Book http://www.tkuhn.ch/bel2nanopub/RAiWyqYH9AcHCUdMEscZUCdgkpRM3l6VSaGw37ZxKrcXs#_4 http://www.w3.org/ns/prov#value Page 442 Feeding rats with a cholesterol-enriched diet induces bile acid synthesis. This increase is attributable to the rise in cyp7a activity, which catalyzes the rate-limiting step of the classical pathway. Interrupting the return of bile acids to the liver, by diverting bile or by feeding a bile acid-binding resin, also stimulates the synthesis of bile acids. In contrast, reintroduction of bile acids into bile-diverted rats reverses the stimulatory effect, indicating that bile acid synthesis is subject to end-product inhibition. It was later discovered that cyp7a enzyme activity is closely correlated with cyp7a mRNA abundance, indicating that cyp7a gene transcription is the major determinant of cyp7a activity. http://www.tkuhn.ch/bel2nanopub/RAiWyqYH9AcHCUdMEscZUCdgkpRM3l6VSaGw37ZxKrcXs#_4 http://www.w3.org/ns/prov#wasQuotedFrom http://www.tkuhn.ch/bel2nanopub/RAiWyqYH9AcHCUdMEscZUCdgkpRM3l6VSaGw37ZxKrcXs#_3 http://www.tkuhn.ch/bel2nanopub/RAiWyqYH9AcHCUdMEscZUCdgkpRM3l6VSaGw37ZxKrcXs#_5 http://www.w3.org/2000/01/rdf-schema#label Selventa http://www.tkuhn.ch/bel2nanopub/RAiWyqYH9AcHCUdMEscZUCdgkpRM3l6VSaGw37ZxKrcXs#assertion http://www.w3.org/ns/prov#hadPrimarySource http://www.tkuhn.ch/bel2nanopub/RAiWyqYH9AcHCUdMEscZUCdgkpRM3l6VSaGw37ZxKrcXs#_3 http://www.tkuhn.ch/bel2nanopub/RAiWyqYH9AcHCUdMEscZUCdgkpRM3l6VSaGw37ZxKrcXs#assertion http://www.w3.org/ns/prov#wasDerivedFrom http://resource.belframework.org/belframework/1.0/knowledge/large_corpus.bel http://www.tkuhn.ch/bel2nanopub/RAiWyqYH9AcHCUdMEscZUCdgkpRM3l6VSaGw37ZxKrcXs#assertion http://www.w3.org/ns/prov#wasDerivedFrom http://www.tkuhn.ch/bel2nanopub/RAiWyqYH9AcHCUdMEscZUCdgkpRM3l6VSaGw37ZxKrcXs#_4 http://www.tkuhn.ch/bel2nanopub/RAiWyqYH9AcHCUdMEscZUCdgkpRM3l6VSaGw37ZxKrcXs#pubinfo http://www.tkuhn.ch/bel2nanopub/RAiWyqYH9AcHCUdMEscZUCdgkpRM3l6VSaGw37ZxKrcXs http://purl.org/dc/terms/created 2014-07-03T14:29:44.571+02:00 http://www.tkuhn.ch/bel2nanopub/RAiWyqYH9AcHCUdMEscZUCdgkpRM3l6VSaGw37ZxKrcXs http://purl.org/pav/createdBy http://orcid.org/0000-0001-6818-334X http://www.tkuhn.ch/bel2nanopub/RAiWyqYH9AcHCUdMEscZUCdgkpRM3l6VSaGw37ZxKrcXs http://purl.org/pav/createdBy http://orcid.org/0000-0002-1267-0234