http://www.tkuhn.ch/bel2nanopub/RAiXR5rE8ZZYaA84hBW9CZaWqIui2s5EEK0XgWEQG7eu4#Head http://www.tkuhn.ch/bel2nanopub/RAiXR5rE8ZZYaA84hBW9CZaWqIui2s5EEK0XgWEQG7eu4 http://www.nanopub.org/nschema#hasAssertion http://www.tkuhn.ch/bel2nanopub/RAiXR5rE8ZZYaA84hBW9CZaWqIui2s5EEK0XgWEQG7eu4#assertion http://www.tkuhn.ch/bel2nanopub/RAiXR5rE8ZZYaA84hBW9CZaWqIui2s5EEK0XgWEQG7eu4 http://www.nanopub.org/nschema#hasProvenance http://www.tkuhn.ch/bel2nanopub/RAiXR5rE8ZZYaA84hBW9CZaWqIui2s5EEK0XgWEQG7eu4#provenance http://www.tkuhn.ch/bel2nanopub/RAiXR5rE8ZZYaA84hBW9CZaWqIui2s5EEK0XgWEQG7eu4 http://www.nanopub.org/nschema#hasPublicationInfo http://www.tkuhn.ch/bel2nanopub/RAiXR5rE8ZZYaA84hBW9CZaWqIui2s5EEK0XgWEQG7eu4#pubinfo http://www.tkuhn.ch/bel2nanopub/RAiXR5rE8ZZYaA84hBW9CZaWqIui2s5EEK0XgWEQG7eu4 http://www.w3.org/1999/02/22-rdf-syntax-ns#type http://www.nanopub.org/nschema#Nanopublication http://www.tkuhn.ch/bel2nanopub/RAiXR5rE8ZZYaA84hBW9CZaWqIui2s5EEK0XgWEQG7eu4#assertion http://www.tkuhn.ch/bel2nanopub/RAiXR5rE8ZZYaA84hBW9CZaWqIui2s5EEK0XgWEQG7eu4#_1 http://purl.obolibrary.org/obo/BFO_0000051 http://www.tkuhn.ch/bel2nanopub/RAiXR5rE8ZZYaA84hBW9CZaWqIui2s5EEK0XgWEQG7eu4#_2 http://www.tkuhn.ch/bel2nanopub/RAiXR5rE8ZZYaA84hBW9CZaWqIui2s5EEK0XgWEQG7eu4#_1 http://purl.obolibrary.org/obo/BFO_0000051 http://www.tkuhn.ch/bel2nanopub/RAiXR5rE8ZZYaA84hBW9CZaWqIui2s5EEK0XgWEQG7eu4#_3 http://www.tkuhn.ch/bel2nanopub/RAiXR5rE8ZZYaA84hBW9CZaWqIui2s5EEK0XgWEQG7eu4#_1 http://www.w3.org/1999/02/22-rdf-syntax-ns#type http://amigo.geneontology.org/amigo/term/GO:0043234 http://www.tkuhn.ch/bel2nanopub/RAiXR5rE8ZZYaA84hBW9CZaWqIui2s5EEK0XgWEQG7eu4#_2 http://purl.obolibrary.org/obo/RO_0002204 http://www.genenames.org/cgi-bin/gene_symbol_report?hgnc_id=4566 http://www.tkuhn.ch/bel2nanopub/RAiXR5rE8ZZYaA84hBW9CZaWqIui2s5EEK0XgWEQG7eu4#_2 http://www.w3.org/1999/02/22-rdf-syntax-ns#type http://www.ebi.ac.uk/chebi/searchId.do?chebiId=CHEBI_36080 http://www.tkuhn.ch/bel2nanopub/RAiXR5rE8ZZYaA84hBW9CZaWqIui2s5EEK0XgWEQG7eu4#_3 http://purl.obolibrary.org/obo/RO_0002204 http://www.genenames.org/cgi-bin/gene_symbol_report?hgnc_id=2662 http://www.tkuhn.ch/bel2nanopub/RAiXR5rE8ZZYaA84hBW9CZaWqIui2s5EEK0XgWEQG7eu4#_3 http://www.w3.org/1999/02/22-rdf-syntax-ns#type http://www.ebi.ac.uk/chebi/searchId.do?chebiId=CHEBI_36080 http://www.tkuhn.ch/bel2nanopub/RAiXR5rE8ZZYaA84hBW9CZaWqIui2s5EEK0XgWEQG7eu4#_4 http://semanticscience.org/resource/SIO_000139 http://www.tkuhn.ch/bel2nanopub/RAiXR5rE8ZZYaA84hBW9CZaWqIui2s5EEK0XgWEQG7eu4#_5 http://www.tkuhn.ch/bel2nanopub/RAiXR5rE8ZZYaA84hBW9CZaWqIui2s5EEK0XgWEQG7eu4#_4 http://www.w3.org/1999/02/22-rdf-syntax-ns#type http://amigo.geneontology.org/amigo/term/GO:0016301 http://www.tkuhn.ch/bel2nanopub/RAiXR5rE8ZZYaA84hBW9CZaWqIui2s5EEK0XgWEQG7eu4#_5 http://purl.obolibrary.org/obo/RO_0002204 http://www.genenames.org/cgi-bin/gene_symbol_report?hgnc_id=6871 http://www.tkuhn.ch/bel2nanopub/RAiXR5rE8ZZYaA84hBW9CZaWqIui2s5EEK0XgWEQG7eu4#_5 http://www.w3.org/1999/02/22-rdf-syntax-ns#type http://www.ebi.ac.uk/chebi/searchId.do?chebiId=CHEBI_36080 http://www.tkuhn.ch/bel2nanopub/RAiXR5rE8ZZYaA84hBW9CZaWqIui2s5EEK0XgWEQG7eu4#_6 http://purl.obolibrary.org/obo/BFO_0000066 http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?id=9606 http://www.tkuhn.ch/bel2nanopub/RAiXR5rE8ZZYaA84hBW9CZaWqIui2s5EEK0XgWEQG7eu4#_6 http://www.w3.org/1999/02/22-rdf-syntax-ns#object http://www.tkuhn.ch/bel2nanopub/RAiXR5rE8ZZYaA84hBW9CZaWqIui2s5EEK0XgWEQG7eu4#_4 http://www.tkuhn.ch/bel2nanopub/RAiXR5rE8ZZYaA84hBW9CZaWqIui2s5EEK0XgWEQG7eu4#_6 http://www.w3.org/1999/02/22-rdf-syntax-ns#predicate http://www.selventa.com/vocabulary/decreases http://www.tkuhn.ch/bel2nanopub/RAiXR5rE8ZZYaA84hBW9CZaWqIui2s5EEK0XgWEQG7eu4#_6 http://www.w3.org/1999/02/22-rdf-syntax-ns#subject http://www.tkuhn.ch/bel2nanopub/RAiXR5rE8ZZYaA84hBW9CZaWqIui2s5EEK0XgWEQG7eu4#_1 http://www.tkuhn.ch/bel2nanopub/RAiXR5rE8ZZYaA84hBW9CZaWqIui2s5EEK0XgWEQG7eu4#_6 http://www.w3.org/1999/02/22-rdf-syntax-ns#type http://www.w3.org/1999/02/22-rdf-syntax-ns#Statement http://www.tkuhn.ch/bel2nanopub/RAiXR5rE8ZZYaA84hBW9CZaWqIui2s5EEK0XgWEQG7eu4#assertion http://www.w3.org/2000/01/rdf-schema#label complex(p(HGNC:GRB2),p(HGNC:DAB2)) -| kin(p(HGNC:MAPK1)) http://www.tkuhn.ch/bel2nanopub/RAiXR5rE8ZZYaA84hBW9CZaWqIui2s5EEK0XgWEQG7eu4#provenance http://resource.belframework.org/belframework/1.0/knowledge/large_corpus.bel http://purl.org/dc/elements/1.1/description Approximately 61,000 statements. http://resource.belframework.org/belframework/1.0/knowledge/large_corpus.bel http://purl.org/dc/elements/1.1/rights Copyright (c) 2011-2012, Selventa. All rights reserved. http://resource.belframework.org/belframework/1.0/knowledge/large_corpus.bel http://purl.org/dc/elements/1.1/title BEL Framework Large Corpus Document http://resource.belframework.org/belframework/1.0/knowledge/large_corpus.bel http://purl.org/pav/authoredBy http://www.tkuhn.ch/bel2nanopub/RAiXR5rE8ZZYaA84hBW9CZaWqIui2s5EEK0XgWEQG7eu4#_8 http://resource.belframework.org/belframework/1.0/knowledge/large_corpus.bel http://purl.org/pav/version 1.4 http://www.tkuhn.ch/bel2nanopub/RAiXR5rE8ZZYaA84hBW9CZaWqIui2s5EEK0XgWEQG7eu4#_7 http://www.w3.org/ns/prov#value Using sequence-specific peptides, we found that the second proline-rich domain of DOC-2/DAB2 is the key binding site to Grb2 in the presence of growth factors. Such elevated binding interrupts the binding between SOS and Grb2, which consequently suppresses downstream ERK phosphorylation. Reduced ERK phosphorylation was restored when the binding between DOC-2/DAB2 and Grb2 was interrupted by a specific peptide or by increasing the expression of Grb2. http://www.tkuhn.ch/bel2nanopub/RAiXR5rE8ZZYaA84hBW9CZaWqIui2s5EEK0XgWEQG7eu4#_7 http://www.w3.org/ns/prov#wasQuotedFrom http://www.ncbi.nlm.nih.gov/pubmed/11371563 http://www.tkuhn.ch/bel2nanopub/RAiXR5rE8ZZYaA84hBW9CZaWqIui2s5EEK0XgWEQG7eu4#_8 http://www.w3.org/2000/01/rdf-schema#label Selventa http://www.tkuhn.ch/bel2nanopub/RAiXR5rE8ZZYaA84hBW9CZaWqIui2s5EEK0XgWEQG7eu4#assertion http://www.w3.org/ns/prov#hadPrimarySource http://www.ncbi.nlm.nih.gov/pubmed/11371563 http://www.tkuhn.ch/bel2nanopub/RAiXR5rE8ZZYaA84hBW9CZaWqIui2s5EEK0XgWEQG7eu4#assertion http://www.w3.org/ns/prov#wasDerivedFrom http://resource.belframework.org/belframework/1.0/knowledge/large_corpus.bel http://www.tkuhn.ch/bel2nanopub/RAiXR5rE8ZZYaA84hBW9CZaWqIui2s5EEK0XgWEQG7eu4#assertion http://www.w3.org/ns/prov#wasDerivedFrom http://www.tkuhn.ch/bel2nanopub/RAiXR5rE8ZZYaA84hBW9CZaWqIui2s5EEK0XgWEQG7eu4#_7 http://www.tkuhn.ch/bel2nanopub/RAiXR5rE8ZZYaA84hBW9CZaWqIui2s5EEK0XgWEQG7eu4#pubinfo http://www.tkuhn.ch/bel2nanopub/RAiXR5rE8ZZYaA84hBW9CZaWqIui2s5EEK0XgWEQG7eu4 http://purl.org/dc/terms/created 2014-07-03T14:29:56.296+02:00 http://www.tkuhn.ch/bel2nanopub/RAiXR5rE8ZZYaA84hBW9CZaWqIui2s5EEK0XgWEQG7eu4 http://purl.org/pav/createdBy http://orcid.org/0000-0001-6818-334X http://www.tkuhn.ch/bel2nanopub/RAiXR5rE8ZZYaA84hBW9CZaWqIui2s5EEK0XgWEQG7eu4 http://purl.org/pav/createdBy http://orcid.org/0000-0002-1267-0234