. . . . . . . . . . . . . . . . . "cat(p(HGNC:PLG)) -> cat(p(HGNC:PLAU))" . "Approximately 61,000 statements." . "Copyright (c) 2011-2012, Selventa. All rights reserved." . "BEL Framework Large Corpus Document" . . "1.4" . "Several types of proteolytic enzymes have been identified to specifically degrade the proteins of the extracellular matrix: matrix metalloproteinases (MMPs) [5], cysteine proteases [6], and serine proteases [7]. Serine protease urokinase-type plasminogen activator (uPA) is a protease that cleaves the extracellular matrix and stimulates the conversion of plasminogen to plasmin [8]. Plasmin mediates invasion directly, by degrading matrix proteins such as collagen IV, fibronectin, and laminin, or indirectly, by activating matrix metalloproteinases MMP-2, -3, and -9 and serine protease uPA [9-12]. uPA exerts its nonproteolytic activity through its interaction with uPA receptor (uPAR), which forms the complex with integrins and controls cell adhesion and cell migration [" . . "Selventa" . . . . "2014-07-03T14:30:23.984+02:00"^^ . . .