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All rights reserved. http://resource.belframework.org/belframework/1.0/knowledge/large_corpus.bel http://purl.org/dc/elements/1.1/title BEL Framework Large Corpus Document http://resource.belframework.org/belframework/1.0/knowledge/large_corpus.bel http://purl.org/pav/authoredBy http://www.tkuhn.ch/bel2nanopub/RAijrE_cT1O0fTc1UdsEzG_ZtMJRClq-clxiAzcEB-zAo#_6 http://resource.belframework.org/belframework/1.0/knowledge/large_corpus.bel http://purl.org/pav/version 1.4 http://www.tkuhn.ch/bel2nanopub/RAijrE_cT1O0fTc1UdsEzG_ZtMJRClq-clxiAzcEB-zAo#_5 http://www.w3.org/ns/prov#value Jung et al. [36] recently investigated TNF-a-induced HIF-1a accumulation and demonstrated that an NFkB-mediated event that is normally associated with inflammation and cell survival caused protein accumulation in normoxic cells. Although the report fails to identify the mechanism of HIF-1a accumulation, it is suggested that this might interfere with the pVHL-mediated HIF-1a degradation process. Further studies support the concept of a pVHL-dependent cytotoxicity to TNF-a in RCC cells [37,38]. In particular, it has been reported that RCC cells can be sensitized to TNF-a-induced cytotoxicity by re-introducing wild-type VHL [38]. The authors highlight the fact that TNFreceptor engagement by TNF-a triggers the activation of atypical protein kinase C (aPKC), which, through IKKb phosphorylation, liberates NFkB, thereby initiating the transcription of genes that are involved in apoptosis. http://www.tkuhn.ch/bel2nanopub/RAijrE_cT1O0fTc1UdsEzG_ZtMJRClq-clxiAzcEB-zAo#_5 http://www.w3.org/ns/prov#wasQuotedFrom http://www.ncbi.nlm.nih.gov/pubmed/15350900 http://www.tkuhn.ch/bel2nanopub/RAijrE_cT1O0fTc1UdsEzG_ZtMJRClq-clxiAzcEB-zAo#_6 http://www.w3.org/2000/01/rdf-schema#label Selventa http://www.tkuhn.ch/bel2nanopub/RAijrE_cT1O0fTc1UdsEzG_ZtMJRClq-clxiAzcEB-zAo#assertion http://www.w3.org/ns/prov#hadPrimarySource http://www.ncbi.nlm.nih.gov/pubmed/15350900 http://www.tkuhn.ch/bel2nanopub/RAijrE_cT1O0fTc1UdsEzG_ZtMJRClq-clxiAzcEB-zAo#assertion http://www.w3.org/ns/prov#wasDerivedFrom http://resource.belframework.org/belframework/1.0/knowledge/large_corpus.bel http://www.tkuhn.ch/bel2nanopub/RAijrE_cT1O0fTc1UdsEzG_ZtMJRClq-clxiAzcEB-zAo#assertion http://www.w3.org/ns/prov#wasDerivedFrom http://www.tkuhn.ch/bel2nanopub/RAijrE_cT1O0fTc1UdsEzG_ZtMJRClq-clxiAzcEB-zAo#_5 http://www.tkuhn.ch/bel2nanopub/RAijrE_cT1O0fTc1UdsEzG_ZtMJRClq-clxiAzcEB-zAo#pubinfo http://www.tkuhn.ch/bel2nanopub/RAijrE_cT1O0fTc1UdsEzG_ZtMJRClq-clxiAzcEB-zAo http://purl.org/dc/terms/created 2014-07-03T14:30:27.339+02:00 http://www.tkuhn.ch/bel2nanopub/RAijrE_cT1O0fTc1UdsEzG_ZtMJRClq-clxiAzcEB-zAo http://purl.org/pav/createdBy http://orcid.org/0000-0001-6818-334X http://www.tkuhn.ch/bel2nanopub/RAijrE_cT1O0fTc1UdsEzG_ZtMJRClq-clxiAzcEB-zAo http://purl.org/pav/createdBy http://orcid.org/0000-0002-1267-0234