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All rights reserved. http://resource.belframework.org/belframework/1.0/knowledge/large_corpus.bel http://purl.org/dc/elements/1.1/title BEL Framework Large Corpus Document http://resource.belframework.org/belframework/1.0/knowledge/large_corpus.bel http://purl.org/pav/authoredBy http://www.tkuhn.ch/bel2nanopub/RAixH6HpHhXP_LooJJMGhAGkWWcauEGAgD2XBpeltgB24#_6 http://resource.belframework.org/belframework/1.0/knowledge/large_corpus.bel http://purl.org/pav/version 1.4 http://www.tkuhn.ch/bel2nanopub/RAixH6HpHhXP_LooJJMGhAGkWWcauEGAgD2XBpeltgB24#_5 http://www.w3.org/ns/prov#value DAF-16 and its mammalian homologues, including FKHR (FOXO1), FKHRL1 (FOXO3a), and AFX (FOXO4) interact directly with IRSs from the IGFBP-1 promoter in a sequence-specific fashion in in vitro assays and in cells. In liver-derived cells, FOXO proteins stimulate the activity of promoters for IGFBP-1, glucose-6 phosphatase, and PEPCK. In other cell types, FOXO proteins also stimulate the expression of proteins that inhibit cell cycle progression, including p27Kip, Rb2, and GADD45, and proteins that promote cells death, including Bim and Fas ligand. http://www.tkuhn.ch/bel2nanopub/RAixH6HpHhXP_LooJJMGhAGkWWcauEGAgD2XBpeltgB24#_5 http://www.w3.org/ns/prov#wasQuotedFrom http://www.ncbi.nlm.nih.gov/pubmed/12228231 http://www.tkuhn.ch/bel2nanopub/RAixH6HpHhXP_LooJJMGhAGkWWcauEGAgD2XBpeltgB24#_6 http://www.w3.org/2000/01/rdf-schema#label Selventa http://www.tkuhn.ch/bel2nanopub/RAixH6HpHhXP_LooJJMGhAGkWWcauEGAgD2XBpeltgB24#assertion http://www.w3.org/ns/prov#hadPrimarySource http://www.ncbi.nlm.nih.gov/pubmed/12228231 http://www.tkuhn.ch/bel2nanopub/RAixH6HpHhXP_LooJJMGhAGkWWcauEGAgD2XBpeltgB24#assertion http://www.w3.org/ns/prov#wasDerivedFrom http://resource.belframework.org/belframework/1.0/knowledge/large_corpus.bel http://www.tkuhn.ch/bel2nanopub/RAixH6HpHhXP_LooJJMGhAGkWWcauEGAgD2XBpeltgB24#assertion http://www.w3.org/ns/prov#wasDerivedFrom http://www.tkuhn.ch/bel2nanopub/RAixH6HpHhXP_LooJJMGhAGkWWcauEGAgD2XBpeltgB24#_5 http://www.tkuhn.ch/bel2nanopub/RAixH6HpHhXP_LooJJMGhAGkWWcauEGAgD2XBpeltgB24#pubinfo http://www.tkuhn.ch/bel2nanopub/RAixH6HpHhXP_LooJJMGhAGkWWcauEGAgD2XBpeltgB24 http://purl.org/dc/terms/created 2014-07-03T14:30:05.905+02:00 http://www.tkuhn.ch/bel2nanopub/RAixH6HpHhXP_LooJJMGhAGkWWcauEGAgD2XBpeltgB24 http://purl.org/pav/createdBy http://orcid.org/0000-0001-6818-334X http://www.tkuhn.ch/bel2nanopub/RAixH6HpHhXP_LooJJMGhAGkWWcauEGAgD2XBpeltgB24 http://purl.org/pav/createdBy http://orcid.org/0000-0002-1267-0234