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All rights reserved. http://resource.belframework.org/belframework/1.0/knowledge/large_corpus.bel http://purl.org/dc/elements/1.1/title BEL Framework Large Corpus Document http://resource.belframework.org/belframework/1.0/knowledge/large_corpus.bel http://purl.org/pav/authoredBy http://www.tkuhn.ch/bel2nanopub/RAiz-hkrqXAFc2O8v3nAL8P5_vf5jDU8GLHeA7no0iNX4#_4 http://resource.belframework.org/belframework/1.0/knowledge/large_corpus.bel http://purl.org/pav/version 1.4 http://www.tkuhn.ch/bel2nanopub/RAiz-hkrqXAFc2O8v3nAL8P5_vf5jDU8GLHeA7no0iNX4#_3 http://www.w3.org/ns/prov#value We show that CSF-1 stimulation of BAC1.2F5 macrophages results in the upregulation of expression of ets2 and bcl-xL with similar kinetics of induction. In the absence of CSF-1, these macrophages undergo cell death by apoptosis, whereas constitutive expression of Ets2 rescues these cells from cell death, and bcl-xL is upregulated. These results strongly suggest a novel role of Ets2 in affecting apoptosis through its regulation of Bcl-xL transcription. http://www.tkuhn.ch/bel2nanopub/RAiz-hkrqXAFc2O8v3nAL8P5_vf5jDU8GLHeA7no0iNX4#_3 http://www.w3.org/ns/prov#wasQuotedFrom http://www.ncbi.nlm.nih.gov/pubmed/10082528 http://www.tkuhn.ch/bel2nanopub/RAiz-hkrqXAFc2O8v3nAL8P5_vf5jDU8GLHeA7no0iNX4#_4 http://www.w3.org/2000/01/rdf-schema#label Selventa http://www.tkuhn.ch/bel2nanopub/RAiz-hkrqXAFc2O8v3nAL8P5_vf5jDU8GLHeA7no0iNX4#assertion http://www.w3.org/ns/prov#hadPrimarySource http://www.ncbi.nlm.nih.gov/pubmed/10082528 http://www.tkuhn.ch/bel2nanopub/RAiz-hkrqXAFc2O8v3nAL8P5_vf5jDU8GLHeA7no0iNX4#assertion http://www.w3.org/ns/prov#wasDerivedFrom http://resource.belframework.org/belframework/1.0/knowledge/large_corpus.bel http://www.tkuhn.ch/bel2nanopub/RAiz-hkrqXAFc2O8v3nAL8P5_vf5jDU8GLHeA7no0iNX4#assertion http://www.w3.org/ns/prov#wasDerivedFrom http://www.tkuhn.ch/bel2nanopub/RAiz-hkrqXAFc2O8v3nAL8P5_vf5jDU8GLHeA7no0iNX4#_3 http://www.tkuhn.ch/bel2nanopub/RAiz-hkrqXAFc2O8v3nAL8P5_vf5jDU8GLHeA7no0iNX4#pubinfo http://www.tkuhn.ch/bel2nanopub/RAiz-hkrqXAFc2O8v3nAL8P5_vf5jDU8GLHeA7no0iNX4 http://purl.org/dc/terms/created 2014-07-03T14:29:46.223+02:00 http://www.tkuhn.ch/bel2nanopub/RAiz-hkrqXAFc2O8v3nAL8P5_vf5jDU8GLHeA7no0iNX4 http://purl.org/pav/createdBy http://orcid.org/0000-0001-6818-334X http://www.tkuhn.ch/bel2nanopub/RAiz-hkrqXAFc2O8v3nAL8P5_vf5jDU8GLHeA7no0iNX4 http://purl.org/pav/createdBy http://orcid.org/0000-0002-1267-0234