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All rights reserved. http://resource.belframework.org/belframework/1.0/knowledge/large_corpus.bel http://purl.org/dc/elements/1.1/title BEL Framework Large Corpus Document http://resource.belframework.org/belframework/1.0/knowledge/large_corpus.bel http://purl.org/pav/authoredBy http://www.tkuhn.ch/bel2nanopub/RAjH-seQ5DjYCNsCIM4_p8LF5OyIgs4x5Y_0w-a_7HadI#_4 http://resource.belframework.org/belframework/1.0/knowledge/large_corpus.bel http://purl.org/pav/version 1.4 http://www.tkuhn.ch/bel2nanopub/RAjH-seQ5DjYCNsCIM4_p8LF5OyIgs4x5Y_0w-a_7HadI#_3 http://www.w3.org/ns/prov#value ZAG has recently been shown to be directly synthesized by white (and brown) adipocytes, there being a powerful upregulation at both the gene expression and protein levels in mice bearing the MAC16 tumour (a model for cachexia) (Bing et al. 2004). ZAG mRNA was increased 10-fold in the WAT of tumourbearing mice, while the level of leptin mRNA was reduced some 30-fold (Bing et al. 2004). In studies using human SGBS (Simpson-Golabi-Behmel syndrome) adipocytes, ZAG has now been shown to be released from fat cells, indicating that it is an adipokine (Bao et al. 2005). 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