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All rights reserved. http://resource.belframework.org/belframework/1.0/knowledge/large_corpus.bel http://purl.org/dc/elements/1.1/title BEL Framework Large Corpus Document http://resource.belframework.org/belframework/1.0/knowledge/large_corpus.bel http://purl.org/pav/authoredBy http://www.tkuhn.ch/bel2nanopub/RAjK-l7cbf5Htp_91Tqd4BuP8PaWYBs84bS73PreifwJU#_5 http://resource.belframework.org/belframework/1.0/knowledge/large_corpus.bel http://purl.org/pav/version 1.4 http://www.tkuhn.ch/bel2nanopub/RAjK-l7cbf5Htp_91Tqd4BuP8PaWYBs84bS73PreifwJU#_4 http://www.w3.org/ns/prov#value Bay 11-7082, an inhibitor of I{kappa}B phosphorylation, and NF-{kappa}B activation was used to determine whether chemokine induction by PGN is NF-{kappa}B dependent. Concentrations of Bay 11-7082 between 1.0 and 5 µM were used according to published studies. RA synovial fibroblasts were pretreated with Bay 11-7082 for 30 min, washed and subsequently stimulated with PGN for 4 h. Total RNA was then extracted and RANTES, GCP-2, and MCP-2 mRNA quantified by real-time PCR. There was a dose-dependent decrease of mRNA levels of the tested chemokines ranging from marked reduction upon treatment with 1 µM Bay 11-7082 to almost complete inhibition in the RA synovial fibroblasts pretreated with 5 µM Bay 11-7082. http://www.tkuhn.ch/bel2nanopub/RAjK-l7cbf5Htp_91Tqd4BuP8PaWYBs84bS73PreifwJU#_4 http://www.w3.org/ns/prov#wasQuotedFrom http://www.ncbi.nlm.nih.gov/pubmed/14707104 http://www.tkuhn.ch/bel2nanopub/RAjK-l7cbf5Htp_91Tqd4BuP8PaWYBs84bS73PreifwJU#_5 http://www.w3.org/2000/01/rdf-schema#label Selventa http://www.tkuhn.ch/bel2nanopub/RAjK-l7cbf5Htp_91Tqd4BuP8PaWYBs84bS73PreifwJU#assertion http://www.w3.org/ns/prov#hadPrimarySource http://www.ncbi.nlm.nih.gov/pubmed/14707104 http://www.tkuhn.ch/bel2nanopub/RAjK-l7cbf5Htp_91Tqd4BuP8PaWYBs84bS73PreifwJU#assertion http://www.w3.org/ns/prov#wasDerivedFrom http://resource.belframework.org/belframework/1.0/knowledge/large_corpus.bel http://www.tkuhn.ch/bel2nanopub/RAjK-l7cbf5Htp_91Tqd4BuP8PaWYBs84bS73PreifwJU#assertion http://www.w3.org/ns/prov#wasDerivedFrom http://www.tkuhn.ch/bel2nanopub/RAjK-l7cbf5Htp_91Tqd4BuP8PaWYBs84bS73PreifwJU#_4 http://www.tkuhn.ch/bel2nanopub/RAjK-l7cbf5Htp_91Tqd4BuP8PaWYBs84bS73PreifwJU#pubinfo http://www.tkuhn.ch/bel2nanopub/RAjK-l7cbf5Htp_91Tqd4BuP8PaWYBs84bS73PreifwJU http://purl.org/dc/terms/created 2014-07-03T14:30:19.471+02:00 http://www.tkuhn.ch/bel2nanopub/RAjK-l7cbf5Htp_91Tqd4BuP8PaWYBs84bS73PreifwJU http://purl.org/pav/createdBy http://orcid.org/0000-0001-6818-334X http://www.tkuhn.ch/bel2nanopub/RAjK-l7cbf5Htp_91Tqd4BuP8PaWYBs84bS73PreifwJU http://purl.org/pav/createdBy http://orcid.org/0000-0002-1267-0234