@prefix go: <http://amigo.geneontology.org/amigo/term/GO:> .
@prefix this: <http://www.tkuhn.ch/bel2nanopub/RAjYLON2jowcpAY94IDidfotH3I4uhMvmZyuBpeBRoP1s> .
@prefix sub: <http://www.tkuhn.ch/bel2nanopub/RAjYLON2jowcpAY94IDidfotH3I4uhMvmZyuBpeBRoP1s#> .
@prefix beldoc: <http://resource.belframework.org/belframework/1.0/knowledge/large_corpus.bel> .
@prefix rdfs: <http://www.w3.org/2000/01/rdf-schema#> .
@prefix rdf: <http://www.w3.org/1999/02/22-rdf-syntax-ns#> .
@prefix xsd: <http://www.w3.org/2001/XMLSchema#> .
@prefix dct: <http://purl.org/dc/terms/> .
@prefix dce: <http://purl.org/dc/elements/1.1/> .
@prefix pav: <http://purl.org/pav/> .
@prefix np: <http://www.nanopub.org/nschema#> .
@prefix belv: <http://www.selventa.com/vocabulary/> .
@prefix prov: <http://www.w3.org/ns/prov#> .
@prefix Protein: <http://www.ebi.ac.uk/chebi/searchId.do?chebiId=CHEBI_36080> .
@prefix hgnc: <http://www.genenames.org/cgi-bin/gene_symbol_report?hgnc_id=> .
@prefix geneProductOf: <http://purl.obolibrary.org/obo/RO_0002204> .
@prefix mesh: <http://purl.bioontology.org/ontology/MSH/> .
@prefix occursIn: <http://purl.obolibrary.org/obo/BFO_0000066> .
@prefix species: <http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?id=> .
@prefix pubmed: <http://www.ncbi.nlm.nih.gov/pubmed/> .
@prefix orcid: <http://orcid.org/> .

sub:Head {
  this: np:hasAssertion sub:assertion;
    np:hasProvenance sub:provenance;
    np:hasPublicationInfo sub:pubinfo;
    a np:Nanopublication .
}

sub:assertion {
  sub:_1 geneProductOf: hgnc:12428;
    a Protein: .
  
  sub:_2 belv:translocationFrom go:0005622;
    belv:translocationOf sub:_3;
    belv:translocationTo go:0009986 .
  
  sub:_3 geneProductOf: hgnc:2514;
    a Protein: .
  
  sub:_4 occursIn: mesh:D001940, mesh:D004848, species:9606;
    rdf:object sub:_2;
    rdf:predicate belv:decreases;
    rdf:subject sub:_1;
    a rdf:Statement .
  
  sub:assertion rdfs:label "p(HGNC:TWIST1) -| surf(p(HGNC:CTNNB1))" .
}

sub:provenance {
  beldoc: dce:description "Approximately 61,000 statements.";
    dce:rights "Copyright (c) 2011-2012, Selventa. All rights reserved.";
    dce:title "BEL Framework Large Corpus Document";
    pav:authoredBy sub:_6;
    pav:version "1.4" .
  
  sub:_5 prov:value "This morphological change represents one of the hallmarks of an EMT. To determine whether the molecular alterations of an EMT occurred in these cells, we examined the localization of several adherens junction proteins, such as E-cadherin, alpha-catenin, beta-catenin, and gamma-catenin. Immunostaining showed that all four proteins disappeared from cell membrane in the Twist-express- ing MDCK cells compared to their strong membrane staining in the control cells (Figure 5B). We also observed complete loss of E-cadherin, alpha-catenin, and gamma-catenin proteins by immunoblotting (Figure 5C). In contrast, the expression of fibroblast markers, including fibronectin, vimentin, smooth-muscle actin, and N-cad- herin, whose expression has been shown to correlate positively with the EMT (Boyer and Thiery, 1993), was strongly induced (Figures 5B and 5C). Hence, both the morphological and molecular changes in the Twistexpressing MDCK cells demonstrated that these cells had undergone an EMT.";
    prov:wasQuotedFrom pubmed:15210113 .
  
  sub:_6 rdfs:label "Selventa" .
  
  sub:assertion prov:hadPrimarySource pubmed:15210113;
    prov:wasDerivedFrom beldoc:, sub:_5 .
}

sub:pubinfo {
  this: dct:created "2014-07-03T14:30:25.109+02:00"^^xsd:dateTime;
    pav:createdBy orcid:0000-0001-6818-334X, orcid:0000-0002-1267-0234 .
}