sub:provenance {
beldoc: dce:description "Approximately 61,000 statements." ;
dce:rights "Copyright (c) 2011-2012, Selventa. All rights reserved." ;
dce:title "BEL Framework Large Corpus Document" ;
pav:authoredBy sub:_4 ;
pav:version "1.4" .
sub:_3 prov:value "# Ariadne: On the basis of our current results and those of others (Legay et al., 1995 ; see also Fontaine and Changeux, 1989 ; Tsay and Schmidt, 1989 ; Piette et al., 1993 ), it appears that during synaptogenesis and maturation of the neuromuscular junction, the activity-linked regulation of the AChE gene involves transcriptional and posttranscriptional regulatory mechanisms and that, in mature muscle, regulation of this synaptic protein is achieved primarily via posttranscriptional events. [Regulation] The molecular mechanisms underlying the activity-linked plasticity of acetylcholinesterase (AChE) mRNA levels in mammalian skeletal muscle have yet to be established. Here, we demonstrate that denervation of adult muscle induces a dramatic (up to 90%) and rapid (within 24 h) decrease in the abundance of AChE mRNAs." ;
prov:wasQuotedFrom pubmed:10820184 .
sub:_4 rdfs:label "Selventa" .
sub:assertion prov:hadPrimarySource pubmed:10820184 ;
prov:wasDerivedFrom beldoc: ,
sub:_3 .
}