@prefix dc: <http://purl.org/dc/terms/> .
@prefix this: <http://www.tkuhn.ch/bel2nanopub/RAjkTUoLt7coa48MQ_sBhAL3y39rviG9BGObzkf5iimy0> .
@prefix sub: <http://www.tkuhn.ch/bel2nanopub/RAjkTUoLt7coa48MQ_sBhAL3y39rviG9BGObzkf5iimy0#> .
@prefix beldoc: <http://resource.belframework.org/belframework/20131211/knowledge/small_corpus.bel> .
@prefix rdfs: <http://www.w3.org/2000/01/rdf-schema#> .
@prefix rdf: <http://www.w3.org/1999/02/22-rdf-syntax-ns#> .
@prefix xsd: <http://www.w3.org/2001/XMLSchema#> .
@prefix dce: <http://purl.org/dc/elements/1.1/> .
@prefix pav: <http://purl.org/pav/> .
@prefix np: <http://www.nanopub.org/nschema#> .
@prefix belv: <http://www.selventa.com/vocabulary/> .
@prefix prov: <http://www.w3.org/ns/prov#> .
@prefix hgnc: <http://www.genenames.org/cgi-bin/gene_symbol_report?hgnc_id=> .
@prefix proteinModification: <http://www.ebi.ac.uk/ontology-lookup/?termId=MOD:00000> .
@prefix psimod: <http://www.ebi.ac.uk/ontology-lookup/?termId=MOD:> .
@prefix go: <http://amigo.geneontology.org/amigo/term/GO:> .
@prefix Protein: <http://www.ebi.ac.uk/chebi/searchId.do?chebiId=CHEBI_36080> .
@prefix geneProductOf: <http://purl.obolibrary.org/obo/RO_0002204> .
@prefix hasPart: <http://purl.obolibrary.org/obo/BFO_0000051> .
@prefix ProteinComplex: <http://amigo.geneontology.org/amigo/term/GO:0043234> .
@prefix hasAgent: <http://semanticscience.org/resource/SIO_000139> .
@prefix hasAnnotation: <http://semanticscience.org/resource/SIO_000255> .
@prefix species: <http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?id=> .
@prefix occursIn: <http://purl.obolibrary.org/obo/BFO_0000066> .
@prefix pubmed: <http://www.ncbi.nlm.nih.gov/pubmed/> .
@prefix orcid: <http://orcid.org/> .
sub:Head {
   this: np:hasAssertion sub:assertion ;
    np:hasProvenance sub:provenance ;
    np:hasPublicationInfo sub:pubinfo ;
    a np:Nanopublication .
}
sub:assertion {
   sub:_1 belv:variantOf hgnc:4910 ;
    a proteinModification: , psimod:00696 .
  sub:_10 geneProductOf: hgnc:4910 ;
    a Protein: .
  sub:_11 rdf:object sub:_9 ;
    rdf:predicate belv:directlyIncreases ;
    rdf:subject sub:_2 ;
    a rdf:Statement .
  sub:_12 occursIn: species:9606 ;
    hasAnnotation: sub:_13 ;
    rdf:object sub:_11 ;
    rdf:predicate belv:directlyIncreases ;
    rdf:subject sub:_1 ;
    a rdf:Statement .
  sub:_13 dc:subject "TextLocation" ;
    rdf:value "Review" .
  sub:_2 hasAgent: sub:_3 ;
    a go:0003824 .
  sub:_3 hasPart: sub:_4 , sub:_5 , sub:_6 , sub:_7 , sub:_8 ;
    a ProteinComplex: .
  sub:_4 geneProductOf: hgnc:12687 ;
    a Protein: .
  sub:_5 geneProductOf: hgnc:11617 ;
    a Protein: .
  sub:_6 geneProductOf: hgnc:11619 ;
    a Protein: .
  sub:_7 geneProductOf: hgnc:9928 ;
    a Protein: .
  sub:_8 geneProductOf: hgnc:2552 ;
    a Protein: .
  sub:_9 belv:degradationOf sub:_10 .
  sub:assertion rdfs:label "cat(complex(p(HGNC:VHL),p(HGNC:TCEB1),p(HGNC:TCEB2),p(HGNC:RBX1),p(HGNC:CUL2))) => deg(p(HGNC:HIF1A))" , "p(HGNC:HIF1A,pmod(P,H)) => (cat(complex(p(HGNC:VHL),p(HGNC:TCEB1),p(HGNC:TCEB2),p(HGNC:RBX1),p(HGNC:CUL2))) => deg(p(HGNC:HIF1A)))" .
}
sub:provenance {
   beldoc: dce:description "Approximately 2000 hand curated statements drawn from 57 PubMeds." ;
    dce:rights "Copyright (c) 2011-2012, Selventa. All Rights Reserved." ;
    dce:title "BEL Framework Small Corpus Document" ;
    dc:license "Creative Commons Attribution-Non-Commercial-ShareAlike 3.0 Unported License" ;
    pav:authoredBy sub:_15 ;
    pav:version "20131211" .
  sub:_14 prov:value """The stabilization of HIF in response to hypoxia involves the inactivation of prolylhydroxylases
that modify HIF at specific proline residues in an oxygendependent
manner. Proline hydroxylation marks HIF for degradation by the VCB–Cul2 E3 ligase
complex (Figure 3 and Box 1).""" ;
    prov:wasQuotedFrom pubmed:15350900 .
  sub:_15 rdfs:comment "support@belframework.org" ;
    rdfs:label "Selventa" .
  sub:assertion prov:hadPrimarySource pubmed:15350900 ;
    prov:wasDerivedFrom beldoc: , sub:_14 .
}
sub:pubinfo {
   this: dc:created "2014-07-03T14:31:15.373+02:00"^^xsd:dateTime ;
    pav:createdBy orcid:0000-0001-6818-334X , orcid:0000-0002-1267-0234 .
}