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All rights reserved. http://resource.belframework.org/belframework/1.0/knowledge/large_corpus.bel http://purl.org/dc/elements/1.1/title BEL Framework Large Corpus Document http://resource.belframework.org/belframework/1.0/knowledge/large_corpus.bel http://purl.org/pav/authoredBy http://www.tkuhn.ch/bel2nanopub/RAjm8FbHZ7y57y_kBlTcsc3AchUx-3_hG1-lpLfeQnFU8#_4 http://resource.belframework.org/belframework/1.0/knowledge/large_corpus.bel http://purl.org/pav/version 1.4 http://www.tkuhn.ch/bel2nanopub/RAjm8FbHZ7y57y_kBlTcsc3AchUx-3_hG1-lpLfeQnFU8#_3 http://www.w3.org/ns/prov#value To understand the role of the GH/IGF-I axis in liver regeneration, we performed partial hepatectomies in three groups of mice: GH antagonist (GHa) transgenic mice, in which the action of GH is blocked; liver IGF-I-deficient mice that lack IGF-I specifically in the liver and also lack the acid-labile subunit (ALS; LID+ALSKO mice), in which IGF-I levels are very low and GH secretion is increased; and control mice. Interestingly, the survival rate of GHa transgenic mice was dramatically reduced after partial hepatectomy (57%) compared with the survival rate of controls (100%) or LID+ALSKO mice (88%). In control mice, the liver was completely regenerated after 4 d, whereas liver regeneration required 7 d in LID+ALSKO mice. In contrast, in GHa mice, liver regeneration reached only 70% of the original liver mass after 4 d and did not improve thereafter. http://www.tkuhn.ch/bel2nanopub/RAjm8FbHZ7y57y_kBlTcsc3AchUx-3_hG1-lpLfeQnFU8#_3 http://www.w3.org/ns/prov#wasQuotedFrom http://www.ncbi.nlm.nih.gov/pubmed/15242989 http://www.tkuhn.ch/bel2nanopub/RAjm8FbHZ7y57y_kBlTcsc3AchUx-3_hG1-lpLfeQnFU8#_4 http://www.w3.org/2000/01/rdf-schema#label Selventa http://www.tkuhn.ch/bel2nanopub/RAjm8FbHZ7y57y_kBlTcsc3AchUx-3_hG1-lpLfeQnFU8#assertion http://www.w3.org/ns/prov#hadPrimarySource http://www.ncbi.nlm.nih.gov/pubmed/15242989 http://www.tkuhn.ch/bel2nanopub/RAjm8FbHZ7y57y_kBlTcsc3AchUx-3_hG1-lpLfeQnFU8#assertion http://www.w3.org/ns/prov#wasDerivedFrom http://resource.belframework.org/belframework/1.0/knowledge/large_corpus.bel http://www.tkuhn.ch/bel2nanopub/RAjm8FbHZ7y57y_kBlTcsc3AchUx-3_hG1-lpLfeQnFU8#assertion http://www.w3.org/ns/prov#wasDerivedFrom http://www.tkuhn.ch/bel2nanopub/RAjm8FbHZ7y57y_kBlTcsc3AchUx-3_hG1-lpLfeQnFU8#_3 http://www.tkuhn.ch/bel2nanopub/RAjm8FbHZ7y57y_kBlTcsc3AchUx-3_hG1-lpLfeQnFU8#pubinfo http://www.tkuhn.ch/bel2nanopub/RAjm8FbHZ7y57y_kBlTcsc3AchUx-3_hG1-lpLfeQnFU8 http://purl.org/dc/terms/created 2014-07-03T14:30:25.752+02:00 http://www.tkuhn.ch/bel2nanopub/RAjm8FbHZ7y57y_kBlTcsc3AchUx-3_hG1-lpLfeQnFU8 http://purl.org/pav/createdBy http://orcid.org/0000-0001-6818-334X http://www.tkuhn.ch/bel2nanopub/RAjm8FbHZ7y57y_kBlTcsc3AchUx-3_hG1-lpLfeQnFU8 http://purl.org/pav/createdBy http://orcid.org/0000-0002-1267-0234