@prefix dc: <
http://purl.org/dc/terms/
> .
@prefix this: <
http://www.tkuhn.ch/bel2nanopub/RAjuueY2vdO6zm8wodxHvHjfdGhhBuBWlMwoInxdJ5uLk
> .
@prefix sub: <
http://www.tkuhn.ch/bel2nanopub/RAjuueY2vdO6zm8wodxHvHjfdGhhBuBWlMwoInxdJ5uLk#
> .
@prefix beldoc: <
http://resource.belframework.org/belframework/1.0/knowledge/large_corpus.bel
> .
@prefix rdfs: <
http://www.w3.org/2000/01/rdf-schema#
> .
@prefix rdf: <
http://www.w3.org/1999/02/22-rdf-syntax-ns#
> .
@prefix xsd: <
http://www.w3.org/2001/XMLSchema#
> .
@prefix dce: <
http://purl.org/dc/elements/1.1/
> .
@prefix pav: <
http://purl.org/pav/
> .
@prefix np: <
http://www.nanopub.org/nschema#
> .
@prefix belv: <
http://www.selventa.com/vocabulary/
> .
@prefix prov: <
http://www.w3.org/ns/prov#
> .
@prefix chebi: <
http://www.ebi.ac.uk/chebi/searchId.do?chebiId=
> .
@prefix go: <
http://amigo.geneontology.org/amigo/term/GO:
> .
@prefix Protein: <
http://www.ebi.ac.uk/chebi/searchId.do?chebiId=CHEBI_36080
> .
@prefix mgi: <
http://www.informatics.jax.org/marker/MGI:
> .
@prefix geneProductOf: <
http://purl.obolibrary.org/obo/RO_0002204
> .
@prefix hasAgent: <
http://semanticscience.org/resource/SIO_000139
> .
@prefix mesh: <
http://purl.bioontology.org/ontology/MSH/
> .
@prefix occursIn: <
http://purl.obolibrary.org/obo/BFO_0000066
> .
@prefix species: <
http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?id=
> .
@prefix orcid: <
http://orcid.org/
> .
sub:Head
{
this:
np:hasAssertion
sub:assertion
;
np:hasProvenance
sub:provenance
;
np:hasPublicationInfo
sub:pubinfo
;
a
np:Nanopublication
.
}
sub:assertion
{
sub:_1
hasAgent:
sub:_2
;
a
go:0042789
.
sub:_2
geneProductOf:
mgi:107606
;
a
Protein:
.
sub:_3
occursIn:
mesh:D002462
,
mesh:D009000
,
mesh:D009130
,
mesh:D050197
,
species:10090
;
rdf:object
sub:_1
;
rdf:predicate
belv:decreases
;
rdf:subject
chebi:42977
;
a
rdf:Statement
.
sub:assertion
rdfs:label
"a(CHEBI:\"25-hydroxycholesterol\") -| tscript(p(MGI:Srebf1))" .
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sub:provenance
{
beldoc:
dce:description
"Approximately 61,000 statements." ;
dce:rights
"Copyright (c) 2011-2012, Selventa. All rights reserved." ;
dce:title
"BEL Framework Large Corpus Document" ;
pav:authoredBy
sub:_6
;
pav:version
"1.4" .
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dce:identifier
"Biochemistry of Lipids, Lipoproteins and Membranes 2002 - Chapter 22" ;
dce:title
"Biochemistry of Lipids, Lipoproteins and Membranes 2002 - Chapter 22" ;
dce:type
"Book" .
sub:_5
prov:value
"Both cholesterol and certain oxysterols, such as 25OH and 7K, suppress the proteolytic activation of sterol response element binding protein. This in turn leads to transcriptional down regulation of the LDL receptor and certain enzymes in the cholesterol biosynthetic and fatty acid synthesis and metabolic pathways." ;
prov:wasQuotedFrom
sub:_4
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sub:_6
rdfs:label
"Selventa" .
sub:assertion
prov:hadPrimarySource
sub:_4
;
prov:wasDerivedFrom
beldoc:
,
sub:_5
.
}
sub:pubinfo
{
this:
dc:created
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xsd:dateTime
;
pav:createdBy
orcid:0000-0001-6818-334X
,
orcid:0000-0002-1267-0234
.
}