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All rights reserved. http://resource.belframework.org/belframework/1.0/knowledge/large_corpus.bel http://purl.org/dc/elements/1.1/title BEL Framework Large Corpus Document http://resource.belframework.org/belframework/1.0/knowledge/large_corpus.bel http://purl.org/pav/authoredBy http://www.tkuhn.ch/bel2nanopub/RAk6KezX4H3iqmTrY_5dE8dOLn29x3x5_-sO_YplLEGj4#_4 http://resource.belframework.org/belframework/1.0/knowledge/large_corpus.bel http://purl.org/pav/version 1.4 http://www.tkuhn.ch/bel2nanopub/RAk6KezX4H3iqmTrY_5dE8dOLn29x3x5_-sO_YplLEGj4#_3 http://www.w3.org/ns/prov#value Interestingly, ectopic Par-4 overexpression is sufficient to induce apoptosis in most cancer cells, but not in normal or immortalized cells, and this action of Par-4 does not require the leucine zipper domain Apoptosis by ectopic Par-4 involves activation of the Fas death receptor signaling pathway and concurrent nuclear factor-nB (NF-nB) inhibition, which withdraws the antiapoptotic roadblocks and allows the caspase cascade to proceed uninterrupted http://www.tkuhn.ch/bel2nanopub/RAk6KezX4H3iqmTrY_5dE8dOLn29x3x5_-sO_YplLEGj4#_3 http://www.w3.org/ns/prov#wasQuotedFrom http://www.ncbi.nlm.nih.gov/pubmed/16540633 http://www.tkuhn.ch/bel2nanopub/RAk6KezX4H3iqmTrY_5dE8dOLn29x3x5_-sO_YplLEGj4#_4 http://www.w3.org/2000/01/rdf-schema#label Selventa http://www.tkuhn.ch/bel2nanopub/RAk6KezX4H3iqmTrY_5dE8dOLn29x3x5_-sO_YplLEGj4#assertion http://www.w3.org/ns/prov#hadPrimarySource http://www.ncbi.nlm.nih.gov/pubmed/16540633 http://www.tkuhn.ch/bel2nanopub/RAk6KezX4H3iqmTrY_5dE8dOLn29x3x5_-sO_YplLEGj4#assertion http://www.w3.org/ns/prov#wasDerivedFrom http://resource.belframework.org/belframework/1.0/knowledge/large_corpus.bel http://www.tkuhn.ch/bel2nanopub/RAk6KezX4H3iqmTrY_5dE8dOLn29x3x5_-sO_YplLEGj4#assertion http://www.w3.org/ns/prov#wasDerivedFrom http://www.tkuhn.ch/bel2nanopub/RAk6KezX4H3iqmTrY_5dE8dOLn29x3x5_-sO_YplLEGj4#_3 http://www.tkuhn.ch/bel2nanopub/RAk6KezX4H3iqmTrY_5dE8dOLn29x3x5_-sO_YplLEGj4#pubinfo http://www.tkuhn.ch/bel2nanopub/RAk6KezX4H3iqmTrY_5dE8dOLn29x3x5_-sO_YplLEGj4 http://purl.org/dc/terms/created 2014-07-03T14:30:42.031+02:00 http://www.tkuhn.ch/bel2nanopub/RAk6KezX4H3iqmTrY_5dE8dOLn29x3x5_-sO_YplLEGj4 http://purl.org/pav/createdBy http://orcid.org/0000-0001-6818-334X http://www.tkuhn.ch/bel2nanopub/RAk6KezX4H3iqmTrY_5dE8dOLn29x3x5_-sO_YplLEGj4 http://purl.org/pav/createdBy http://orcid.org/0000-0002-1267-0234