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p(HGNC:DVL2) -> gtp(p(HGNC:RHOA))
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p(HGNC:WNT1) -> (p(HGNC:DVL2) -> gtp(p(HGNC:RHOA)))
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Approximately 61,000 statements.
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Copyright (c) 2011-2012, Selventa. All rights reserved.
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BEL Framework Large Corpus Document
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1.4
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The Wnt induced Dvl-RhoA complex requires the endogenous Daam1 protein, because this complex is abolished (Figure 2G) by the expression of either N-Daam1, which binds RhoA but not Dvl, or T-Daam1, which is a fragment from the two-hybrid screen (Figure 2E) and thus binds Dvl but not RhoA. These results suggest that Wnt signaling induces a Dvl-Rho complex formation that is assembled via Daam1.
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Selventa
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2014-07-03T14:30:00.088+02:00
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