@prefix dct: <http://purl.org/dc/terms/> .
@prefix go: <http://amigo.geneontology.org/amigo/term/GO:> .
@prefix this: <http://www.tkuhn.ch/bel2nanopub/RAkH5czqmnSjBrE3ENplLZ6F7WUTKFPkCnloACThQKfkk> .
@prefix sub: <http://www.tkuhn.ch/bel2nanopub/RAkH5czqmnSjBrE3ENplLZ6F7WUTKFPkCnloACThQKfkk#> .
@prefix beldoc: <http://resource.belframework.org/belframework/1.0/knowledge/large_corpus.bel> .
@prefix rdfs: <http://www.w3.org/2000/01/rdf-schema#> .
@prefix rdf: <http://www.w3.org/1999/02/22-rdf-syntax-ns#> .
@prefix xsd: <http://www.w3.org/2001/XMLSchema#> .
@prefix dce: <http://purl.org/dc/elements/1.1/> .
@prefix pav: <http://purl.org/pav/> .
@prefix np: <http://www.nanopub.org/nschema#> .
@prefix belv: <http://www.selventa.com/vocabulary/> .
@prefix prov: <http://www.w3.org/ns/prov#> .
@prefix Protein: <http://www.ebi.ac.uk/chebi/searchId.do?chebiId=CHEBI_36080> .
@prefix mgi: <http://www.informatics.jax.org/marker/MGI:> .
@prefix geneProductOf: <http://purl.obolibrary.org/obo/RO_0002204> .
@prefix species: <http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?id=> .
@prefix occursIn: <http://purl.obolibrary.org/obo/BFO_0000066> .
@prefix pubmed: <http://www.ncbi.nlm.nih.gov/pubmed/> .
@prefix orcid: <http://orcid.org/> .
sub:Head {
   this: np:hasAssertion sub:assertion ;
    np:hasProvenance sub:provenance ;
    np:hasPublicationInfo sub:pubinfo ;
    a np:Nanopublication .
}
sub:assertion {
   sub:_1 geneProductOf: mgi:96537 ;
    a Protein: .
  sub:_2 geneProductOf: mgi:107656 ;
    a Protein: .
  sub:_3 belv:translocationFrom go:0005622 ;
    belv:translocationOf sub:_4 ;
    belv:translocationTo go:0005576 .
  sub:_4 geneProductOf: mgi:88244 ;
    a Protein: .
  sub:_5 rdf:object sub:_3 ;
    rdf:predicate belv:increases ;
    rdf:subject sub:_2 ;
    a rdf:Statement .
  sub:_6 occursIn: species:10090 ;
    rdf:object sub:_5 ;
    rdf:predicate belv:increases ;
    rdf:subject sub:_1 ;
    a rdf:Statement .
  sub:assertion rdfs:label "p(MGI:Ifng) -> sec(p(MGI:S100a8))" , "p(MGI:Il10) -> (p(MGI:Ifng) -> sec(p(MGI:S100a8)))" .
}
sub:provenance {
   beldoc: dce:description "Approximately 61,000 statements." ;
    dce:rights "Copyright (c) 2011-2012, Selventa. All rights reserved." ;
    dce:title "BEL Framework Large Corpus Document" ;
    pav:authoredBy sub:_8 ;
    pav:version "1.4" .
  sub:_7 prov:value "A8 is only expressed in elicited Mac following activation. LPS- (17), IFN-, and TNF-induced gene expression is modulated by Ca2+ and by pathways involving protein kinase (PK)C, leading to activation of mitogen-activated (MA)PK (18). IL-10, but not IL-4 or IL-13, down-regulates MHC class II expression and Ag presentation by monocytes (23) and up-regulates monocyte chemoattractant protein (MCP)-1 production by blood monocytes and alveolar Mac (24, 25), IL-10 strongly synergized with LPS or IFN to markedly enhance A8 secretion. Synergy may involve a cAMP-dependent pathway, acting principally at the level of transcription, and was confined to a small region of the proximal promoter containing binding sites for Ets and CCAAT/enhancer binding protein (C/EBP) transcription factors." ;
    prov:wasQuotedFrom pubmed:11342660 .
  sub:_8 rdfs:label "Selventa" .
  sub:assertion prov:hadPrimarySource pubmed:11342660 ;
    prov:wasDerivedFrom beldoc: , sub:_7 .
}
sub:pubinfo {
   this: dct:created "2014-07-03T14:29:56.046+02:00"^^xsd:dateTime ;
    pav:createdBy orcid:0000-0001-6818-334X , orcid:0000-0002-1267-0234 .
}