. . . . . . . . . . . . . . . . . . . . . . "p(MGI:Ifng) -> sec(p(MGI:S100a8))" . "p(MGI:Il10) -> (p(MGI:Ifng) -> sec(p(MGI:S100a8)))" . "Approximately 61,000 statements." . "Copyright (c) 2011-2012, Selventa. All rights reserved." . "BEL Framework Large Corpus Document" . . "1.4" . "A8 is only expressed in elicited Mac following activation. LPS- (17), IFN-, and TNF-induced gene expression is modulated by Ca2+ and by pathways involving protein kinase (PK)C, leading to activation of mitogen-activated (MA)PK (18). IL-10, but not IL-4 or IL-13, down-regulates MHC class II expression and Ag presentation by monocytes (23) and up-regulates monocyte chemoattractant protein (MCP)-1 production by blood monocytes and alveolar Mac (24, 25), IL-10 strongly synergized with LPS or IFN to markedly enhance A8 secretion. Synergy may involve a cAMP-dependent pathway, acting principally at the level of transcription, and was confined to a small region of the proximal promoter containing binding sites for Ets and CCAAT/enhancer binding protein (C/EBP) transcription factors." . . "Selventa" . . . . "2014-07-03T14:29:56.046+02:00"^^ . . .