[ {
  "@graph" : [ {
    "@id" : "http://www.tkuhn.ch/bel2nanopub/RAkHVlHwF4aCURbew1Lutq_t4I_XgSo413K5suYrCaqJE",
    "@type" : [ "http://www.nanopub.org/nschema#Nanopublication" ],
    "http://www.nanopub.org/nschema#hasAssertion" : [ {
      "@id" : "http://www.tkuhn.ch/bel2nanopub/RAkHVlHwF4aCURbew1Lutq_t4I_XgSo413K5suYrCaqJE#assertion"
    } ],
    "http://www.nanopub.org/nschema#hasProvenance" : [ {
      "@id" : "http://www.tkuhn.ch/bel2nanopub/RAkHVlHwF4aCURbew1Lutq_t4I_XgSo413K5suYrCaqJE#provenance"
    } ],
    "http://www.nanopub.org/nschema#hasPublicationInfo" : [ {
      "@id" : "http://www.tkuhn.ch/bel2nanopub/RAkHVlHwF4aCURbew1Lutq_t4I_XgSo413K5suYrCaqJE#pubinfo"
    } ]
  } ],
  "@id" : "http://www.tkuhn.ch/bel2nanopub/RAkHVlHwF4aCURbew1Lutq_t4I_XgSo413K5suYrCaqJE#Head"
}, {
  "@graph" : [ {
    "@id" : "http://www.tkuhn.ch/bel2nanopub/RAkHVlHwF4aCURbew1Lutq_t4I_XgSo413K5suYrCaqJE#_1",
    "@type" : [ "http://amigo.geneontology.org/amigo/term/GO:0042789" ],
    "http://semanticscience.org/resource/SIO_000139" : [ {
      "@id" : "http://www.tkuhn.ch/bel2nanopub/RAkHVlHwF4aCURbew1Lutq_t4I_XgSo413K5suYrCaqJE#_2"
    } ]
  }, {
    "@id" : "http://www.tkuhn.ch/bel2nanopub/RAkHVlHwF4aCURbew1Lutq_t4I_XgSo413K5suYrCaqJE#_2",
    "@type" : [ "http://www.ebi.ac.uk/chebi/searchId.do?chebiId=CHEBI_36080" ],
    "http://purl.obolibrary.org/obo/RO_0002204" : [ {
      "@id" : "http://rgd.mcw.edu/rgdweb/report/gene/main.html?id=3172"
    } ]
  }, {
    "@id" : "http://www.tkuhn.ch/bel2nanopub/RAkHVlHwF4aCURbew1Lutq_t4I_XgSo413K5suYrCaqJE#_3",
    "@type" : [ "http://www.ebi.ac.uk/chebi/searchId.do?chebiId=CHEBI_33697" ],
    "http://purl.obolibrary.org/obo/RO_0002204" : [ {
      "@id" : "http://rgd.mcw.edu/rgdweb/report/gene/main.html?id=61992"
    } ]
  }, {
    "@id" : "http://www.tkuhn.ch/bel2nanopub/RAkHVlHwF4aCURbew1Lutq_t4I_XgSo413K5suYrCaqJE#_4",
    "@type" : [ "http://www.w3.org/1999/02/22-rdf-syntax-ns#Statement" ],
    "http://purl.obolibrary.org/obo/BFO_0000066" : [ {
      "@id" : "http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?id=10116"
    } ],
    "http://www.w3.org/1999/02/22-rdf-syntax-ns#object" : [ {
      "@id" : "http://www.tkuhn.ch/bel2nanopub/RAkHVlHwF4aCURbew1Lutq_t4I_XgSo413K5suYrCaqJE#_3"
    } ],
    "http://www.w3.org/1999/02/22-rdf-syntax-ns#predicate" : [ {
      "@id" : "http://www.selventa.com/vocabulary/directlyIncreases"
    } ],
    "http://www.w3.org/1999/02/22-rdf-syntax-ns#subject" : [ {
      "@id" : "http://www.tkuhn.ch/bel2nanopub/RAkHVlHwF4aCURbew1Lutq_t4I_XgSo413K5suYrCaqJE#_1"
    } ]
  }, {
    "@id" : "http://www.tkuhn.ch/bel2nanopub/RAkHVlHwF4aCURbew1Lutq_t4I_XgSo413K5suYrCaqJE#assertion",
    "http://www.w3.org/2000/01/rdf-schema#label" : [ {
      "@value" : "tscript(p(RGD:Nfyb)) => r(RGD:Gch1)"
    } ]
  } ],
  "@id" : "http://www.tkuhn.ch/bel2nanopub/RAkHVlHwF4aCURbew1Lutq_t4I_XgSo413K5suYrCaqJE#assertion"
}, {
  "@graph" : [ {
    "@id" : "http://resource.belframework.org/belframework/1.0/knowledge/large_corpus.bel",
    "http://purl.org/dc/elements/1.1/description" : [ {
      "@value" : "Approximately 61,000 statements."
    } ],
    "http://purl.org/dc/elements/1.1/rights" : [ {
      "@value" : "Copyright (c) 2011-2012, Selventa. All rights reserved."
    } ],
    "http://purl.org/dc/elements/1.1/title" : [ {
      "@value" : "BEL Framework Large Corpus Document"
    } ],
    "http://purl.org/pav/authoredBy" : [ {
      "@id" : "http://www.tkuhn.ch/bel2nanopub/RAkHVlHwF4aCURbew1Lutq_t4I_XgSo413K5suYrCaqJE#_6"
    } ],
    "http://purl.org/pav/version" : [ {
      "@value" : "1.4"
    } ]
  }, {
    "@id" : "http://www.tkuhn.ch/bel2nanopub/RAkHVlHwF4aCURbew1Lutq_t4I_XgSo413K5suYrCaqJE#_5",
    "http://www.w3.org/ns/prov#value" : [ {
      "@value" : "The GTP cyclohydrolase I (GTPCH) gene promoter consists of a Sp1/GC box, cAMP-response element (CRE), a CCAAT-box, and an E-box. Three distinct domains were detected in the promoter, Domain1 (+7 to -19, E-box), Domain2 (29-bp, -97 to -69, CAAT-box), Domain4 (-132 to -111, Sp1/Gc box). Promoter transcription was enhanced by 4-7 fold on incubation of PC12 cells with 8-bromo-cyclic AMP. Sp1/GC box sequence inhibited the transcriptional activity. The basal transcription was decreased by 66% on transfection of cells with the mutant CCAAT-box and CRE promoter. Both the CRE and CCAAT-box independently contribute to basal and cAMP-dependent activity. EMSA showed that nuclear proteins from PC12 cells bind the CCAAT-box as a complex containing NFY-B (Nuclear factor Y-B). The results thus demonstrate that NFYB binds to the CCAAT-box of the promoter and confers GTPCH transcriptional activation in response to cAMP."
    } ],
    "http://www.w3.org/ns/prov#wasQuotedFrom" : [ {
      "@id" : "http://www.ncbi.nlm.nih.gov/pubmed/10681588"
    } ]
  }, {
    "@id" : "http://www.tkuhn.ch/bel2nanopub/RAkHVlHwF4aCURbew1Lutq_t4I_XgSo413K5suYrCaqJE#_6",
    "http://www.w3.org/2000/01/rdf-schema#label" : [ {
      "@value" : "Selventa"
    } ]
  }, {
    "@id" : "http://www.tkuhn.ch/bel2nanopub/RAkHVlHwF4aCURbew1Lutq_t4I_XgSo413K5suYrCaqJE#assertion",
    "http://www.w3.org/ns/prov#hadPrimarySource" : [ {
      "@id" : "http://www.ncbi.nlm.nih.gov/pubmed/10681588"
    } ],
    "http://www.w3.org/ns/prov#wasDerivedFrom" : [ {
      "@id" : "http://resource.belframework.org/belframework/1.0/knowledge/large_corpus.bel"
    }, {
      "@id" : "http://www.tkuhn.ch/bel2nanopub/RAkHVlHwF4aCURbew1Lutq_t4I_XgSo413K5suYrCaqJE#_5"
    } ]
  } ],
  "@id" : "http://www.tkuhn.ch/bel2nanopub/RAkHVlHwF4aCURbew1Lutq_t4I_XgSo413K5suYrCaqJE#provenance"
}, {
  "@graph" : [ {
    "@id" : "http://www.tkuhn.ch/bel2nanopub/RAkHVlHwF4aCURbew1Lutq_t4I_XgSo413K5suYrCaqJE",
    "http://purl.org/dc/terms/created" : [ {
      "@type" : "http://www.w3.org/2001/XMLSchema#dateTime",
      "@value" : "2014-07-03T14:29:50.099+02:00"
    } ],
    "http://purl.org/pav/createdBy" : [ {
      "@id" : "http://orcid.org/0000-0001-6818-334X"
    }, {
      "@id" : "http://orcid.org/0000-0002-1267-0234"
    } ]
  } ],
  "@id" : "http://www.tkuhn.ch/bel2nanopub/RAkHVlHwF4aCURbew1Lutq_t4I_XgSo413K5suYrCaqJE#pubinfo"
} ]