@prefix this: <http://www.tkuhn.ch/bel2nanopub/RAkHVlHwF4aCURbew1Lutq_t4I_XgSo413K5suYrCaqJE> .
@prefix sub: <http://www.tkuhn.ch/bel2nanopub/RAkHVlHwF4aCURbew1Lutq_t4I_XgSo413K5suYrCaqJE#> .
@prefix beldoc: <http://resource.belframework.org/belframework/1.0/knowledge/large_corpus.bel> .
@prefix rdfs: <http://www.w3.org/2000/01/rdf-schema#> .
@prefix rdf: <http://www.w3.org/1999/02/22-rdf-syntax-ns#> .
@prefix xsd: <http://www.w3.org/2001/XMLSchema#> .
@prefix dct: <http://purl.org/dc/terms/> .
@prefix dce: <http://purl.org/dc/elements/1.1/> .
@prefix pav: <http://purl.org/pav/> .
@prefix np: <http://www.nanopub.org/nschema#> .
@prefix belv: <http://www.selventa.com/vocabulary/> .
@prefix prov: <http://www.w3.org/ns/prov#> .
@prefix go: <http://amigo.geneontology.org/amigo/term/GO:> .
@prefix Protein: <http://www.ebi.ac.uk/chebi/searchId.do?chebiId=CHEBI_36080> .
@prefix rgd: <http://rgd.mcw.edu/rgdweb/report/gene/main.html?id=> .
@prefix geneProductOf: <http://purl.obolibrary.org/obo/RO_0002204> .
@prefix hasAgent: <http://semanticscience.org/resource/SIO_000139> .
@prefix RNA: <http://www.ebi.ac.uk/chebi/searchId.do?chebiId=CHEBI_33697> .
@prefix species: <http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?id=> .
@prefix occursIn: <http://purl.obolibrary.org/obo/BFO_0000066> .
@prefix pubmed: <http://www.ncbi.nlm.nih.gov/pubmed/> .
@prefix orcid: <http://orcid.org/> .

sub:Head {
  this: np:hasAssertion sub:assertion;
    np:hasProvenance sub:provenance;
    np:hasPublicationInfo sub:pubinfo;
    a np:Nanopublication .
}

sub:assertion {
  sub:_1 hasAgent: sub:_2;
    a go:0042789 .
  
  sub:_2 geneProductOf: rgd:3172;
    a Protein: .
  
  sub:_3 geneProductOf: rgd:61992;
    a RNA: .
  
  sub:_4 occursIn: species:10116;
    rdf:object sub:_3;
    rdf:predicate belv:directlyIncreases;
    rdf:subject sub:_1;
    a rdf:Statement .
  
  sub:assertion rdfs:label "tscript(p(RGD:Nfyb)) => r(RGD:Gch1)" .
}

sub:provenance {
  beldoc: dce:description "Approximately 61,000 statements.";
    dce:rights "Copyright (c) 2011-2012, Selventa. All rights reserved.";
    dce:title "BEL Framework Large Corpus Document";
    pav:authoredBy sub:_6;
    pav:version "1.4" .
  
  sub:_5 prov:value "The GTP cyclohydrolase I (GTPCH) gene promoter consists of a Sp1/GC box, cAMP-response element (CRE), a CCAAT-box, and an E-box. Three distinct domains were detected in the promoter, Domain1 (+7 to -19, E-box), Domain2 (29-bp, -97 to -69, CAAT-box), Domain4 (-132 to -111, Sp1/Gc box). Promoter transcription was enhanced by 4-7 fold on incubation of PC12 cells with 8-bromo-cyclic AMP. Sp1/GC box sequence inhibited the transcriptional activity. The basal transcription was decreased by 66% on transfection of cells with the mutant CCAAT-box and CRE promoter. Both the CRE and CCAAT-box independently contribute to basal and cAMP-dependent activity. EMSA showed that nuclear proteins from PC12 cells bind the CCAAT-box as a complex containing NFY-B (Nuclear factor Y-B). The results thus demonstrate that NFYB binds to the CCAAT-box of the promoter and confers GTPCH transcriptional activation in response to cAMP.";
    prov:wasQuotedFrom pubmed:10681588 .
  
  sub:_6 rdfs:label "Selventa" .
  
  sub:assertion prov:hadPrimarySource pubmed:10681588;
    prov:wasDerivedFrom beldoc:, sub:_5 .
}

sub:pubinfo {
  this: dct:created "2014-07-03T14:29:50.099+02:00"^^xsd:dateTime;
    pav:createdBy orcid:0000-0001-6818-334X, orcid:0000-0002-1267-0234 .
}