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All rights reserved. http://resource.belframework.org/belframework/1.0/knowledge/large_corpus.bel http://purl.org/dc/elements/1.1/title BEL Framework Large Corpus Document http://resource.belframework.org/belframework/1.0/knowledge/large_corpus.bel http://purl.org/pav/authoredBy http://www.tkuhn.ch/bel2nanopub/RAkHVlHwF4aCURbew1Lutq_t4I_XgSo413K5suYrCaqJE#_6 http://resource.belframework.org/belframework/1.0/knowledge/large_corpus.bel http://purl.org/pav/version 1.4 http://www.tkuhn.ch/bel2nanopub/RAkHVlHwF4aCURbew1Lutq_t4I_XgSo413K5suYrCaqJE#_5 http://www.w3.org/ns/prov#value The GTP cyclohydrolase I (GTPCH) gene promoter consists of a Sp1/GC box, cAMP-response element (CRE), a CCAAT-box, and an E-box. Three distinct domains were detected in the promoter, Domain1 (+7 to -19, E-box), Domain2 (29-bp, -97 to -69, CAAT-box), Domain4 (-132 to -111, Sp1/Gc box). Promoter transcription was enhanced by 4-7 fold on incubation of PC12 cells with 8-bromo-cyclic AMP. Sp1/GC box sequence inhibited the transcriptional activity. The basal transcription was decreased by 66% on transfection of cells with the mutant CCAAT-box and CRE promoter. Both the CRE and CCAAT-box independently contribute to basal and cAMP-dependent activity. EMSA showed that nuclear proteins from PC12 cells bind the CCAAT-box as a complex containing NFY-B (Nuclear factor Y-B). The results thus demonstrate that NFYB binds to the CCAAT-box of the promoter and confers GTPCH transcriptional activation in response to cAMP. http://www.tkuhn.ch/bel2nanopub/RAkHVlHwF4aCURbew1Lutq_t4I_XgSo413K5suYrCaqJE#_5 http://www.w3.org/ns/prov#wasQuotedFrom http://www.ncbi.nlm.nih.gov/pubmed/10681588 http://www.tkuhn.ch/bel2nanopub/RAkHVlHwF4aCURbew1Lutq_t4I_XgSo413K5suYrCaqJE#_6 http://www.w3.org/2000/01/rdf-schema#label Selventa http://www.tkuhn.ch/bel2nanopub/RAkHVlHwF4aCURbew1Lutq_t4I_XgSo413K5suYrCaqJE#assertion http://www.w3.org/ns/prov#hadPrimarySource http://www.ncbi.nlm.nih.gov/pubmed/10681588 http://www.tkuhn.ch/bel2nanopub/RAkHVlHwF4aCURbew1Lutq_t4I_XgSo413K5suYrCaqJE#assertion http://www.w3.org/ns/prov#wasDerivedFrom http://resource.belframework.org/belframework/1.0/knowledge/large_corpus.bel http://www.tkuhn.ch/bel2nanopub/RAkHVlHwF4aCURbew1Lutq_t4I_XgSo413K5suYrCaqJE#assertion http://www.w3.org/ns/prov#wasDerivedFrom http://www.tkuhn.ch/bel2nanopub/RAkHVlHwF4aCURbew1Lutq_t4I_XgSo413K5suYrCaqJE#_5 http://www.tkuhn.ch/bel2nanopub/RAkHVlHwF4aCURbew1Lutq_t4I_XgSo413K5suYrCaqJE#pubinfo http://www.tkuhn.ch/bel2nanopub/RAkHVlHwF4aCURbew1Lutq_t4I_XgSo413K5suYrCaqJE http://purl.org/dc/terms/created 2014-07-03T14:29:50.099+02:00 http://www.tkuhn.ch/bel2nanopub/RAkHVlHwF4aCURbew1Lutq_t4I_XgSo413K5suYrCaqJE http://purl.org/pav/createdBy http://orcid.org/0000-0001-6818-334X http://www.tkuhn.ch/bel2nanopub/RAkHVlHwF4aCURbew1Lutq_t4I_XgSo413K5suYrCaqJE http://purl.org/pav/createdBy http://orcid.org/0000-0002-1267-0234