sub:provenance {
  beldoc: dce:description "Approximately 61,000 statements." ;
    dce:rights "Copyright (c) 2011-2012, Selventa. All rights reserved." ;
    dce:title "BEL Framework Large Corpus Document" ;
    pav:authoredBy sub:_5 ;
    pav:version "1.4" .
  sub:_4 prov:value "Interestingly, co-expression of DSCR1 strongly inhibited the induction of the IL-2 reporter by co-stimulation with PMA and ionophore. Similarly, DSCR1115-197, the truncated version of DSCR1 that retained CaNA binding activity, was able to act as a dose-dependent inhibitor, though not as efficiently as DSCR1 full-length. In contrast, co-expression of DSCR11-156, the mutant incapable of CaNA binding, had no effect on the activation assay, strongly suggesting that the inhibition caused by DSCR1 is mediated through calcineurin binding. ZAKI-4 was also able to inhibit calcineurin function, as measured by its ability to suppress IL-2 reporter activation (Fig. 5A)." ;
    prov:wasQuotedFrom pubmed:10861295 .
  sub:_5 rdfs:label "Selventa" .
  sub:assertion prov:hadPrimarySource pubmed:10861295 ;
    prov:wasDerivedFrom beldoc: , sub:_4 .
}