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All rights reserved. http://resource.belframework.org/belframework/1.0/knowledge/large_corpus.bel http://purl.org/dc/elements/1.1/title BEL Framework Large Corpus Document http://resource.belframework.org/belframework/1.0/knowledge/large_corpus.bel http://purl.org/pav/authoredBy http://www.tkuhn.ch/bel2nanopub/RAkcl_fTZ8H_8RQ_un1SIl0fbgbknLIys3LGriIZa-tCI#_5 http://resource.belframework.org/belframework/1.0/knowledge/large_corpus.bel http://purl.org/pav/version 1.4 http://www.tkuhn.ch/bel2nanopub/RAkcl_fTZ8H_8RQ_un1SIl0fbgbknLIys3LGriIZa-tCI#_4 http://www.w3.org/ns/prov#value Interestingly, co-expression of DSCR1 strongly inhibited the induction of the IL-2 reporter by co-stimulation with PMA and ionophore. Similarly, DSCR1115-197, the truncated version of DSCR1 that retained CaNA binding activity, was able to act as a dose-dependent inhibitor, though not as efficiently as DSCR1 full-length. In contrast, co-expression of DSCR11-156, the mutant incapable of CaNA binding, had no effect on the activation assay, strongly suggesting that the inhibition caused by DSCR1 is mediated through calcineurin binding. ZAKI-4 was also able to inhibit calcineurin function, as measured by its ability to suppress IL-2 reporter activation (Fig. 5A). http://www.tkuhn.ch/bel2nanopub/RAkcl_fTZ8H_8RQ_un1SIl0fbgbknLIys3LGriIZa-tCI#_4 http://www.w3.org/ns/prov#wasQuotedFrom http://www.ncbi.nlm.nih.gov/pubmed/10861295 http://www.tkuhn.ch/bel2nanopub/RAkcl_fTZ8H_8RQ_un1SIl0fbgbknLIys3LGriIZa-tCI#_5 http://www.w3.org/2000/01/rdf-schema#label Selventa http://www.tkuhn.ch/bel2nanopub/RAkcl_fTZ8H_8RQ_un1SIl0fbgbknLIys3LGriIZa-tCI#assertion http://www.w3.org/ns/prov#hadPrimarySource http://www.ncbi.nlm.nih.gov/pubmed/10861295 http://www.tkuhn.ch/bel2nanopub/RAkcl_fTZ8H_8RQ_un1SIl0fbgbknLIys3LGriIZa-tCI#assertion http://www.w3.org/ns/prov#wasDerivedFrom http://resource.belframework.org/belframework/1.0/knowledge/large_corpus.bel http://www.tkuhn.ch/bel2nanopub/RAkcl_fTZ8H_8RQ_un1SIl0fbgbknLIys3LGriIZa-tCI#assertion http://www.w3.org/ns/prov#wasDerivedFrom http://www.tkuhn.ch/bel2nanopub/RAkcl_fTZ8H_8RQ_un1SIl0fbgbknLIys3LGriIZa-tCI#_4 http://www.tkuhn.ch/bel2nanopub/RAkcl_fTZ8H_8RQ_un1SIl0fbgbknLIys3LGriIZa-tCI#pubinfo http://www.tkuhn.ch/bel2nanopub/RAkcl_fTZ8H_8RQ_un1SIl0fbgbknLIys3LGriIZa-tCI http://purl.org/dc/terms/created 2014-07-03T14:29:51.347+02:00 http://www.tkuhn.ch/bel2nanopub/RAkcl_fTZ8H_8RQ_un1SIl0fbgbknLIys3LGriIZa-tCI http://purl.org/pav/createdBy http://orcid.org/0000-0001-6818-334X http://www.tkuhn.ch/bel2nanopub/RAkcl_fTZ8H_8RQ_un1SIl0fbgbknLIys3LGriIZa-tCI http://purl.org/pav/createdBy http://orcid.org/0000-0002-1267-0234