@prefix this: <http://www.tkuhn.ch/bel2nanopub/RAkebrxmitURuUCJ-16I6ZC3dFb11Kj15rpA0UFAM8B5Q> .
@prefix sub: <http://www.tkuhn.ch/bel2nanopub/RAkebrxmitURuUCJ-16I6ZC3dFb11Kj15rpA0UFAM8B5Q#> .
@prefix beldoc: <http://resource.belframework.org/belframework/1.0/knowledge/large_corpus.bel> .
@prefix rdfs: <http://www.w3.org/2000/01/rdf-schema#> .
@prefix rdf: <http://www.w3.org/1999/02/22-rdf-syntax-ns#> .
@prefix xsd: <http://www.w3.org/2001/XMLSchema#> .
@prefix dct: <http://purl.org/dc/terms/> .
@prefix dce: <http://purl.org/dc/elements/1.1/> .
@prefix pav: <http://purl.org/pav/> .
@prefix np: <http://www.nanopub.org/nschema#> .
@prefix belv: <http://www.selventa.com/vocabulary/> .
@prefix prov: <http://www.w3.org/ns/prov#> .
@prefix go: <http://amigo.geneontology.org/amigo/term/GO:> .
@prefix Protein: <http://www.ebi.ac.uk/chebi/searchId.do?chebiId=CHEBI_36080> .
@prefix hgnc: <http://www.genenames.org/cgi-bin/gene_symbol_report?hgnc_id=> .
@prefix geneProductOf: <http://purl.obolibrary.org/obo/RO_0002204> .
@prefix hasPart: <http://purl.obolibrary.org/obo/BFO_0000051> .
@prefix ProteinComplex: <http://amigo.geneontology.org/amigo/term/GO:0043234> .
@prefix hasAgent: <http://semanticscience.org/resource/SIO_000139> .
@prefix species: <http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?id=> .
@prefix occursIn: <http://purl.obolibrary.org/obo/BFO_0000066> .
@prefix mesh: <http://purl.bioontology.org/ontology/MSH/> .
@prefix pubmed: <http://www.ncbi.nlm.nih.gov/pubmed/> .
@prefix orcid: <http://orcid.org/> .
sub:Head {
   this: np:hasAssertion sub:assertion ;
    np:hasProvenance sub:provenance ;
    np:hasPublicationInfo sub:pubinfo ;
    a np:Nanopublication .
}
sub:assertion {
   sub:_1 hasAgent: sub:_2 ;
    a go:0003824 .
  sub:_2 hasPart: sub:_3 , sub:_4 ;
    a ProteinComplex: .
  sub:_3 geneProductOf: hgnc:6150 ;
    a Protein: .
  sub:_4 geneProductOf: hgnc:6156 ;
    a Protein: .
  sub:_5 hasPart: sub:_6 , sub:_7 , sub:_8 ;
    a ProteinComplex: .
  sub:_6 geneProductOf: hgnc:3535 ;
    a Protein: .
  sub:_7 geneProductOf: hgnc:6150 ;
    a Protein: .
  sub:_8 geneProductOf: hgnc:6156 ;
    a Protein: .
  sub:_9 occursIn: mesh:D004730 , species:9606 ;
    rdf:object sub:_5 ;
    rdf:predicate belv:directlyIncreases ;
    rdf:subject sub:_1 ;
    a rdf:Statement .
  sub:assertion rdfs:label "cat(complex(p(HGNC:ITGAV),p(HGNC:ITGB3))) => complex(p(HGNC:F2),p(HGNC:ITGAV),p(HGNC:ITGB3))" .
}
sub:provenance {
   beldoc: dce:description "Approximately 61,000 statements." ;
    dce:rights "Copyright (c) 2011-2012, Selventa. All rights reserved." ;
    dce:title "BEL Framework Large Corpus Document" ;
    pav:authoredBy sub:_11 ;
    pav:version "1.4" .
  sub:_10 prov:value "Our results show that VEGF can induce activation of the key integrins involved in angiogenesis, thereby establishing a mechanism by which the VEGF/VEGFR system can regulate cellular adhesive and migratory responses. Prothrombin, recently identified as an activation- dependent ligand of aVb3 (Byzova and Plow, 1998), supported limited adhesion of nonstimulated HUVECs; however, when these cells were stimulated with as little as 10 ng/ml VEGF165, adhesion to prothrombin increased by more than 10-fold. The increment in adhesion was similar to that induced by PMA" ;
    prov:wasQuotedFrom pubmed:11090623 .
  sub:_11 rdfs:label "Selventa" .
  sub:assertion prov:hadPrimarySource pubmed:11090623 ;
    prov:wasDerivedFrom beldoc: , sub:_10 .
}
sub:pubinfo {
   this: dct:created "2014-07-03T14:29:53.280+02:00"^^xsd:dateTime ;
    pav:createdBy orcid:0000-0001-6818-334X , orcid:0000-0002-1267-0234 .
}