sub:provenance { beldoc:dce:description "Approximately 2000 hand curated statements drawn from 57 PubMeds." ; dce:rights "Copyright (c) 2011-2012, Selventa. All Rights Reserved." ; dce:title "BEL Framework Small Corpus Document" ; dc:license "Creative Commons Attribution-Non-Commercial-ShareAlike 3.0 Unported License" ; pav:authoredBysub:_7 ; pav:version "1.6" . sub:_6prov:value """CaMKIV has been shown to phosphorylate and activate many proteins, including CREB. Because CREB has been shown to be an important activator of PGC-1α gene expression in the fasted liver (24), we used the dominant-negative ACREB protein to examine a potential role for CREB in the CaMKIV-mediated control of the PGC-1α promoter. Although ACREB alone had no effect on the PGC-1α promoter, this protein severely reduced the activation of the PGC-1α promoter by CaMKIV alone or CaMKIV in combination with CnA (Fig. 1A).""" ; prov:wasQuotedFrompubmed:12764228 . sub:_7rdfs:comment "support@belframework.org" ; rdfs:label "Selventa" . sub:assertionprov:hadPrimarySourcepubmed:12764228 ; prov:wasDerivedFrombeldoc: , sub:_6 . }