sub:provenance {
  beldoc: dce:description "Approximately 61,000 statements." ;
    dce:rights "Copyright (c) 2011-2012, Selventa. All rights reserved." ;
    dce:title "BEL Framework Large Corpus Document" ;
    pav:authoredBy sub:_6 ;
    pav:version "1.4" .
  sub:_5 prov:value "To examine whether HRG-induced membrane dynamics and beta -catenin nuclear translocation lead to increased beta -catenin/TCF·LEF signaling, we examined the effect of HRG on the transcriptional activation from a synthetic LEF/beta -catenin responsive promoter construct containing three LEF·TCF binding sites. As shown in Fig. 3A, suppression of PI 3-kinase by LY294002 or a dominant-negative mutant of the p85 subunit of PI 3-kinase (5), as well as its downstream effector AKT, was accompanied by blockade of beta -catenin nuclear signaling-associated transactivation from the LEF·TCF promoter in HRG-treated cells. " ;
    prov:wasQuotedFrom pubmed:11328805 .
  sub:_6 rdfs:label "Selventa" .
  sub:assertion prov:hadPrimarySource pubmed:11328805 ;
    prov:wasDerivedFrom beldoc: , sub:_5 .
}