. . . . . . . . . . . . . . . . . "p(HGNC:NRG1) -> tscript(p(HGNC:CTNNB1))" . "Approximately 61,000 statements." . "Copyright (c) 2011-2012, Selventa. All rights reserved." . "BEL Framework Large Corpus Document" . . "1.4" . "To examine whether HRG-induced membrane dynamics and beta -catenin nuclear translocation lead to increased beta -catenin/TCF·LEF signaling, we examined the effect of HRG on the transcriptional activation from a synthetic LEF/beta -catenin responsive promoter construct containing three LEF·TCF binding sites. As shown in Fig. 3A, suppression of PI 3-kinase by LY294002 or a dominant-negative mutant of the p85 subunit of PI 3-kinase (5), as well as its downstream effector AKT, was accompanied by blockade of beta -catenin nuclear signaling-associated transactivation from the LEF·TCF promoter in HRG-treated cells. " . . "Selventa" . . . . "2014-07-03T14:29:55.781+02:00"^^ . . .