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All rights reserved. http://resource.belframework.org/belframework/1.0/knowledge/large_corpus.bel http://purl.org/dc/elements/1.1/title BEL Framework Large Corpus Document http://resource.belframework.org/belframework/1.0/knowledge/large_corpus.bel http://purl.org/pav/authoredBy http://www.tkuhn.ch/bel2nanopub/RAkzHmy24ppffDlo2mtPKQLoBf6ufp4i77NiW5uUCORQQ#_6 http://resource.belframework.org/belframework/1.0/knowledge/large_corpus.bel http://purl.org/pav/version 1.4 http://www.tkuhn.ch/bel2nanopub/RAkzHmy24ppffDlo2mtPKQLoBf6ufp4i77NiW5uUCORQQ#_5 http://www.w3.org/ns/prov#value To examine whether HRG-induced membrane dynamics and beta -catenin nuclear translocation lead to increased beta -catenin/TCF·LEF signaling, we examined the effect of HRG on the transcriptional activation from a synthetic LEF/beta -catenin responsive promoter construct containing three LEF·TCF binding sites. As shown in Fig. 3A, suppression of PI 3-kinase by LY294002 or a dominant-negative mutant of the p85 subunit of PI 3-kinase (5), as well as its downstream effector AKT, was accompanied by blockade of beta -catenin nuclear signaling-associated transactivation from the LEF·TCF promoter in HRG-treated cells. http://www.tkuhn.ch/bel2nanopub/RAkzHmy24ppffDlo2mtPKQLoBf6ufp4i77NiW5uUCORQQ#_5 http://www.w3.org/ns/prov#wasQuotedFrom http://www.ncbi.nlm.nih.gov/pubmed/11328805 http://www.tkuhn.ch/bel2nanopub/RAkzHmy24ppffDlo2mtPKQLoBf6ufp4i77NiW5uUCORQQ#_6 http://www.w3.org/2000/01/rdf-schema#label Selventa http://www.tkuhn.ch/bel2nanopub/RAkzHmy24ppffDlo2mtPKQLoBf6ufp4i77NiW5uUCORQQ#assertion http://www.w3.org/ns/prov#hadPrimarySource http://www.ncbi.nlm.nih.gov/pubmed/11328805 http://www.tkuhn.ch/bel2nanopub/RAkzHmy24ppffDlo2mtPKQLoBf6ufp4i77NiW5uUCORQQ#assertion http://www.w3.org/ns/prov#wasDerivedFrom http://resource.belframework.org/belframework/1.0/knowledge/large_corpus.bel http://www.tkuhn.ch/bel2nanopub/RAkzHmy24ppffDlo2mtPKQLoBf6ufp4i77NiW5uUCORQQ#assertion http://www.w3.org/ns/prov#wasDerivedFrom http://www.tkuhn.ch/bel2nanopub/RAkzHmy24ppffDlo2mtPKQLoBf6ufp4i77NiW5uUCORQQ#_5 http://www.tkuhn.ch/bel2nanopub/RAkzHmy24ppffDlo2mtPKQLoBf6ufp4i77NiW5uUCORQQ#pubinfo http://www.tkuhn.ch/bel2nanopub/RAkzHmy24ppffDlo2mtPKQLoBf6ufp4i77NiW5uUCORQQ http://purl.org/dc/terms/created 2014-07-03T14:29:55.781+02:00 http://www.tkuhn.ch/bel2nanopub/RAkzHmy24ppffDlo2mtPKQLoBf6ufp4i77NiW5uUCORQQ http://purl.org/pav/createdBy http://orcid.org/0000-0001-6818-334X http://www.tkuhn.ch/bel2nanopub/RAkzHmy24ppffDlo2mtPKQLoBf6ufp4i77NiW5uUCORQQ http://purl.org/pav/createdBy http://orcid.org/0000-0002-1267-0234