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All rights reserved. http://resource.belframework.org/belframework/1.0/knowledge/large_corpus.bel http://purl.org/dc/elements/1.1/title BEL Framework Large Corpus Document http://resource.belframework.org/belframework/1.0/knowledge/large_corpus.bel http://purl.org/pav/authoredBy http://www.tkuhn.ch/bel2nanopub/RAlDDr_5L2f0dafDmXStneUUIe8fA2AjX1d6iqwvXmIOw#_6 http://resource.belframework.org/belframework/1.0/knowledge/large_corpus.bel http://purl.org/pav/version 1.4 http://www.tkuhn.ch/bel2nanopub/RAlDDr_5L2f0dafDmXStneUUIe8fA2AjX1d6iqwvXmIOw#_5 http://www.w3.org/ns/prov#value Moreover, we show that the repression of AR activity by LY294002 is mediated through phosphorylation and inactivation of GSK3beta, a downstream substrate of PI3K/Akt, which results in the nuclear accumulation of beta-catenin The activation of Akt results in the phosphorylation of a number of downstream substrates such as glycogen synthase kinase (GSK3) It has been shown that GSK3 plays an important role in the Wnt pathway by regulating the degradation of -catenin Recently, a specific protein-protein interaction between -catenin and AR was identified by us and others (22, 23). Through this interaction, -catenin augments the ligand-dependent activity of AR in prostate cancer cells. http://www.tkuhn.ch/bel2nanopub/RAlDDr_5L2f0dafDmXStneUUIe8fA2AjX1d6iqwvXmIOw#_5 http://www.w3.org/ns/prov#wasQuotedFrom http://www.ncbi.nlm.nih.gov/pubmed/12063252 http://www.tkuhn.ch/bel2nanopub/RAlDDr_5L2f0dafDmXStneUUIe8fA2AjX1d6iqwvXmIOw#_6 http://www.w3.org/2000/01/rdf-schema#label Selventa http://www.tkuhn.ch/bel2nanopub/RAlDDr_5L2f0dafDmXStneUUIe8fA2AjX1d6iqwvXmIOw#assertion http://www.w3.org/ns/prov#hadPrimarySource http://www.ncbi.nlm.nih.gov/pubmed/12063252 http://www.tkuhn.ch/bel2nanopub/RAlDDr_5L2f0dafDmXStneUUIe8fA2AjX1d6iqwvXmIOw#assertion http://www.w3.org/ns/prov#wasDerivedFrom http://resource.belframework.org/belframework/1.0/knowledge/large_corpus.bel http://www.tkuhn.ch/bel2nanopub/RAlDDr_5L2f0dafDmXStneUUIe8fA2AjX1d6iqwvXmIOw#assertion http://www.w3.org/ns/prov#wasDerivedFrom http://www.tkuhn.ch/bel2nanopub/RAlDDr_5L2f0dafDmXStneUUIe8fA2AjX1d6iqwvXmIOw#_5 http://www.tkuhn.ch/bel2nanopub/RAlDDr_5L2f0dafDmXStneUUIe8fA2AjX1d6iqwvXmIOw#pubinfo http://www.tkuhn.ch/bel2nanopub/RAlDDr_5L2f0dafDmXStneUUIe8fA2AjX1d6iqwvXmIOw http://purl.org/dc/terms/created 2014-07-03T14:30:03.713+02:00 http://www.tkuhn.ch/bel2nanopub/RAlDDr_5L2f0dafDmXStneUUIe8fA2AjX1d6iqwvXmIOw http://purl.org/pav/createdBy http://orcid.org/0000-0001-6818-334X http://www.tkuhn.ch/bel2nanopub/RAlDDr_5L2f0dafDmXStneUUIe8fA2AjX1d6iqwvXmIOw http://purl.org/pav/createdBy http://orcid.org/0000-0002-1267-0234