@prefix dc: <http://purl.org/dc/terms/> .
@prefix this: <http://www.tkuhn.ch/bel2nanopub/RAlDqMK-6oep2q6i0AOZWFH4qlnyXba0rbFzwTD7FcJZM> .
@prefix sub: <http://www.tkuhn.ch/bel2nanopub/RAlDqMK-6oep2q6i0AOZWFH4qlnyXba0rbFzwTD7FcJZM#> .
@prefix beldoc: <http://resource.belframework.org/belframework/20131211/knowledge/small_corpus.bel> .
@prefix rdfs: <http://www.w3.org/2000/01/rdf-schema#> .
@prefix rdf: <http://www.w3.org/1999/02/22-rdf-syntax-ns#> .
@prefix xsd: <http://www.w3.org/2001/XMLSchema#> .
@prefix dce: <http://purl.org/dc/elements/1.1/> .
@prefix pav: <http://purl.org/pav/> .
@prefix np: <http://www.nanopub.org/nschema#> .
@prefix belv: <http://www.selventa.com/vocabulary/> .
@prefix prov: <http://www.w3.org/ns/prov#> .
@prefix schem: <http://resource.belframework.org/belframework/20131211/namespace/selventa-legacy-chemicals/> .
@prefix obo: <http://purl.obolibrary.org/obo/> .
@prefix Protein: <http://www.ebi.ac.uk/chebi/searchId.do?chebiId=CHEBI_36080> .
@prefix mgi: <http://www.informatics.jax.org/marker/MGI:> .
@prefix geneProductOf: <http://purl.obolibrary.org/obo/RO_0002204> .
@prefix hasPart: <http://purl.obolibrary.org/obo/BFO_0000051> .
@prefix occursIn: <http://purl.obolibrary.org/obo/BFO_0000066> .
@prefix hasAnnotation: <http://semanticscience.org/resource/SIO_000255> .
@prefix species: <http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?id=> .
@prefix pubmed: <http://www.ncbi.nlm.nih.gov/pubmed/> .
@prefix orcid: <http://orcid.org/> .

sub:Head {
  this: np:hasAssertion sub:assertion;
    np:hasProvenance sub:provenance;
    np:hasPublicationInfo sub:pubinfo;
    a np:Nanopublication .
}

sub:assertion {
  sub:_1 hasPart: schem:Lipopolysaccharide, sub:_2 .
  
  sub:_2 geneProductOf: mgi:107656;
    a Protein: .
  
  sub:_3 geneProductOf: mgi:2450016;
    a Protein: .
  
  sub:_4 rdf:object sub:_3;
    rdf:predicate belv:increases;
    rdf:subject sub:_1;
    a rdf:Statement .
  
  sub:_5 occursIn: obo:UBERON_0001986, species:10090;
    hasAnnotation: sub:_6;
    rdf:object sub:_4;
    rdf:predicate belv:decreases;
    rdf:subject schem:SP600125;
    a rdf:Statement .
  
  sub:_6 dc:subject "TextLocation";
    rdf:value "Abstract" .
  
  sub:assertion rdfs:label "a(SCHEM:SP600125) -| (composite(p(MGI:Ifng),a(SCHEM:Lipopolysaccharide)) -> p(MGI:Nox1))",
      "composite(p(MGI:Ifng),a(SCHEM:Lipopolysaccharide)) -> p(MGI:Nox1)" .
}

sub:provenance {
  beldoc: dce:description "Approximately 2000 hand curated statements drawn from 57 PubMeds.";
    dce:rights "Copyright (c) 2011-2012, Selventa. All Rights Reserved.";
    dce:title "BEL Framework Small Corpus Document";
    dc:license "Creative Commons Attribution-Non-Commercial-ShareAlike 3.0 Unported License";
    pav:authoredBy sub:_8;
    pav:version "20131211" .
  
  sub:_7 prov:value """Further, LPS + IFNγ -induced expression of iNOS and Nox1 was attenuated by the mitogen-activated
protein kinase kinase 1/2 (MEK1/2) inhibitor PD98059, the JNK inhibitor
SP600125, the Jak2 inhibitor AG490 and the NFκB inhibitor MG132, but not
by the p38 mitogen-activated protein kinase inhibitor SB203580. LPS + IFNγ stimulated
phosphorylation of ERK, JNK and Jak2, and degradation of IκB, but only Jak2
phosphorylation was sensitive to tripterine (50-200 nM). Further, tripterine
diminished the increased vascular permeability in inflamed air pouches.""";
    prov:wasQuotedFrom pubmed:19508391 .
  
  sub:_8 rdfs:comment "support@belframework.org";
    rdfs:label "Selventa" .
  
  sub:assertion prov:hadPrimarySource pubmed:19508391;
    prov:wasDerivedFrom beldoc:, sub:_7 .
}

sub:pubinfo {
  this: dc:created "2014-07-03T14:31:16.444+02:00"^^xsd:dateTime;
    pav:createdBy orcid:0000-0001-6818-334X, orcid:0000-0002-1267-0234 .
}