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All rights reserved. http://resource.belframework.org/belframework/1.0/knowledge/large_corpus.bel http://purl.org/dc/elements/1.1/title BEL Framework Large Corpus Document http://resource.belframework.org/belframework/1.0/knowledge/large_corpus.bel http://purl.org/pav/authoredBy http://www.tkuhn.ch/bel2nanopub/RAlJHdHk7R2JpHUZwcoLEP8D1MPATpNOPGKKdbkWlnoe4#_5 http://resource.belframework.org/belframework/1.0/knowledge/large_corpus.bel http://purl.org/pav/version 1.4 http://www.tkuhn.ch/bel2nanopub/RAlJHdHk7R2JpHUZwcoLEP8D1MPATpNOPGKKdbkWlnoe4#_4 http://www.w3.org/ns/prov#value To test the hypothesis that changes in the prostanoid profile alter cancer growth, we transduced the retroviral vectors carrying TXA(2) synthase cDNA or PGI(2) synthase cDNA to colon-26 adenocarcinoma cells and subsequently inoculated each transformant to syngeneic BALB/c mice. Tumors derived from TXA(2) synthase transformants grew faster (280%, day 8, versus null-vector control; P < 0.05) and showed more abundant vasculature (204%, versus null-vector control; P < 0.01), whereas tumors from PGI(2) synthase transformants presented opposite effects. http://www.tkuhn.ch/bel2nanopub/RAlJHdHk7R2JpHUZwcoLEP8D1MPATpNOPGKKdbkWlnoe4#_4 http://www.w3.org/ns/prov#wasQuotedFrom http://www.ncbi.nlm.nih.gov/pubmed/11782360 http://www.tkuhn.ch/bel2nanopub/RAlJHdHk7R2JpHUZwcoLEP8D1MPATpNOPGKKdbkWlnoe4#_5 http://www.w3.org/2000/01/rdf-schema#label Selventa http://www.tkuhn.ch/bel2nanopub/RAlJHdHk7R2JpHUZwcoLEP8D1MPATpNOPGKKdbkWlnoe4#assertion http://www.w3.org/ns/prov#hadPrimarySource http://www.ncbi.nlm.nih.gov/pubmed/11782360 http://www.tkuhn.ch/bel2nanopub/RAlJHdHk7R2JpHUZwcoLEP8D1MPATpNOPGKKdbkWlnoe4#assertion http://www.w3.org/ns/prov#wasDerivedFrom http://resource.belframework.org/belframework/1.0/knowledge/large_corpus.bel http://www.tkuhn.ch/bel2nanopub/RAlJHdHk7R2JpHUZwcoLEP8D1MPATpNOPGKKdbkWlnoe4#assertion http://www.w3.org/ns/prov#wasDerivedFrom http://www.tkuhn.ch/bel2nanopub/RAlJHdHk7R2JpHUZwcoLEP8D1MPATpNOPGKKdbkWlnoe4#_4 http://www.tkuhn.ch/bel2nanopub/RAlJHdHk7R2JpHUZwcoLEP8D1MPATpNOPGKKdbkWlnoe4#pubinfo http://www.tkuhn.ch/bel2nanopub/RAlJHdHk7R2JpHUZwcoLEP8D1MPATpNOPGKKdbkWlnoe4 http://purl.org/dc/terms/created 2014-07-03T14:30:00.140+02:00 http://www.tkuhn.ch/bel2nanopub/RAlJHdHk7R2JpHUZwcoLEP8D1MPATpNOPGKKdbkWlnoe4 http://purl.org/pav/createdBy http://orcid.org/0000-0001-6818-334X http://www.tkuhn.ch/bel2nanopub/RAlJHdHk7R2JpHUZwcoLEP8D1MPATpNOPGKKdbkWlnoe4 http://purl.org/pav/createdBy http://orcid.org/0000-0002-1267-0234