sub:provenance {
  beldoc: dce:description "Approximately 2000 hand curated statements drawn from 57 PubMeds." ;
    dce:rights "Copyright (c) 2011-2012, Selventa. All Rights Reserved." ;
    dce:title "BEL Framework Small Corpus Document" ;
    dc:license "Creative Commons Attribution-Non-Commercial-ShareAlike 3.0 Unported License" ;
    pav:authoredBy sub:_7 ;
    pav:version "20131211" .
  sub:_6 prov:value """Co-transfection of luciferase reporter plasmids containing these sequences along with
expression plasmids encoding either an activated β-catenin containing mutations
in the GSK-3h phosphorylation sites (β-catenin/4145) or with a TCF3-VP16 fusion
protein demonstrated that both promoter sequences could be activated by transcriptional
mediators of Wnt signaling (Figs. 7A and B). Addition of both h-catenin/4154
and TCF3-VP16 resulted in cooperative activation of both promoters (Figs.
7A and B). Furthermore, a dominantnegative TCF3 construct repressed both BMP4
and N-myc promoters (Figs. 7C and D). Chromatin immunoprecipitation assays show
that β-catenin associates with the conserved LEF/TCF DNA binding sites located
in the BMP4 and N-myc promoters, indicating direct regulation of these promoters
by canonical Wnt signaling (Figs. 7E and F). Together, these results demonstrate
that BMP4 and Nmyc are targets of Wnt/β-catenin signaling in lung airway epithelium.""" ;
    prov:wasQuotedFrom pubmed:15907834 .
  sub:_7 rdfs:comment "support@belframework.org" ;
    rdfs:label "Selventa" .
  sub:assertion prov:hadPrimarySource pubmed:15907834 ;
    prov:wasDerivedFrom beldoc: , sub:_6 .
}