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All rights reserved. http://resource.belframework.org/belframework/1.0/knowledge/large_corpus.bel http://purl.org/dc/elements/1.1/title BEL Framework Large Corpus Document http://resource.belframework.org/belframework/1.0/knowledge/large_corpus.bel http://purl.org/pav/authoredBy http://www.tkuhn.ch/bel2nanopub/RAlYGRX49Af1--3sqMDysFSBdIUQbxGogugfKlLZ9QVRo#_5 http://resource.belframework.org/belframework/1.0/knowledge/large_corpus.bel http://purl.org/pav/version 1.4 http://www.tkuhn.ch/bel2nanopub/RAlYGRX49Af1--3sqMDysFSBdIUQbxGogugfKlLZ9QVRo#_4 http://www.w3.org/ns/prov#value In most cell types, the NFkB p50-p65 dimer is bound to one of the closely related endogneous inhibitory proteins, collectively referred to as IkB, and is held inactive in the cyotplasm. A variety of extracellular signaling, including LPS, cytokines, stress factors have been reported to activate NFkb through phosphorylation of IkB at serine-32 and serine-36, dissociation of IkB from the complex, and translocation of the p50-p65 dimer fromt he cytolplasm to the nucleus. http://www.tkuhn.ch/bel2nanopub/RAlYGRX49Af1--3sqMDysFSBdIUQbxGogugfKlLZ9QVRo#_4 http://www.w3.org/ns/prov#wasQuotedFrom http://www.ncbi.nlm.nih.gov/pubmed/12882972 http://www.tkuhn.ch/bel2nanopub/RAlYGRX49Af1--3sqMDysFSBdIUQbxGogugfKlLZ9QVRo#_5 http://www.w3.org/2000/01/rdf-schema#label Selventa http://www.tkuhn.ch/bel2nanopub/RAlYGRX49Af1--3sqMDysFSBdIUQbxGogugfKlLZ9QVRo#assertion http://www.w3.org/ns/prov#hadPrimarySource http://www.ncbi.nlm.nih.gov/pubmed/12882972 http://www.tkuhn.ch/bel2nanopub/RAlYGRX49Af1--3sqMDysFSBdIUQbxGogugfKlLZ9QVRo#assertion http://www.w3.org/ns/prov#wasDerivedFrom http://resource.belframework.org/belframework/1.0/knowledge/large_corpus.bel http://www.tkuhn.ch/bel2nanopub/RAlYGRX49Af1--3sqMDysFSBdIUQbxGogugfKlLZ9QVRo#assertion http://www.w3.org/ns/prov#wasDerivedFrom http://www.tkuhn.ch/bel2nanopub/RAlYGRX49Af1--3sqMDysFSBdIUQbxGogugfKlLZ9QVRo#_4 http://www.tkuhn.ch/bel2nanopub/RAlYGRX49Af1--3sqMDysFSBdIUQbxGogugfKlLZ9QVRo#pubinfo http://www.tkuhn.ch/bel2nanopub/RAlYGRX49Af1--3sqMDysFSBdIUQbxGogugfKlLZ9QVRo http://purl.org/dc/terms/created 2014-07-03T14:30:15.039+02:00 http://www.tkuhn.ch/bel2nanopub/RAlYGRX49Af1--3sqMDysFSBdIUQbxGogugfKlLZ9QVRo http://purl.org/pav/createdBy http://orcid.org/0000-0001-6818-334X http://www.tkuhn.ch/bel2nanopub/RAlYGRX49Af1--3sqMDysFSBdIUQbxGogugfKlLZ9QVRo http://purl.org/pav/createdBy http://orcid.org/0000-0002-1267-0234