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All rights reserved. http://resource.belframework.org/belframework/1.0/knowledge/large_corpus.bel http://purl.org/dc/elements/1.1/title BEL Framework Large Corpus Document http://resource.belframework.org/belframework/1.0/knowledge/large_corpus.bel http://purl.org/pav/authoredBy http://www.tkuhn.ch/bel2nanopub/RAlj88H6Mg-njFAeQaiTw2ZzS36rQXuKEZB0i5pgj5LAU#_3 http://resource.belframework.org/belframework/1.0/knowledge/large_corpus.bel http://purl.org/pav/version 1.4 http://www.tkuhn.ch/bel2nanopub/RAlj88H6Mg-njFAeQaiTw2ZzS36rQXuKEZB0i5pgj5LAU#_2 http://www.w3.org/ns/prov#value Superoxide anions are generated by means of single-electron reduction of molecular oxygen in complexes of the mitochondrial ETC (figure 1). Particularly, their production depends on the concentration of the intermediate metabolites of these complexes, and the ETC carriers in a more reduced state are capable of donating electrons to oxygen [7,20,22]. The reduced state of the ETC carriers can be achieved by an increased production of reducing equivalents in mitochondria or by a decreased electron transfer capability on (or after) these carriers [20-22]. 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