http://www.tkuhn.ch/bel2nanopub/RAljxBRWrFMDlVSGrRPx4AAwk1X6KowagjpSKjlGBKQGk#Head http://www.tkuhn.ch/bel2nanopub/RAljxBRWrFMDlVSGrRPx4AAwk1X6KowagjpSKjlGBKQGk http://www.nanopub.org/nschema#hasAssertion http://www.tkuhn.ch/bel2nanopub/RAljxBRWrFMDlVSGrRPx4AAwk1X6KowagjpSKjlGBKQGk#assertion http://www.tkuhn.ch/bel2nanopub/RAljxBRWrFMDlVSGrRPx4AAwk1X6KowagjpSKjlGBKQGk http://www.nanopub.org/nschema#hasProvenance http://www.tkuhn.ch/bel2nanopub/RAljxBRWrFMDlVSGrRPx4AAwk1X6KowagjpSKjlGBKQGk#provenance http://www.tkuhn.ch/bel2nanopub/RAljxBRWrFMDlVSGrRPx4AAwk1X6KowagjpSKjlGBKQGk http://www.nanopub.org/nschema#hasPublicationInfo http://www.tkuhn.ch/bel2nanopub/RAljxBRWrFMDlVSGrRPx4AAwk1X6KowagjpSKjlGBKQGk#pubinfo http://www.tkuhn.ch/bel2nanopub/RAljxBRWrFMDlVSGrRPx4AAwk1X6KowagjpSKjlGBKQGk http://www.w3.org/1999/02/22-rdf-syntax-ns#type http://www.nanopub.org/nschema#Nanopublication http://www.tkuhn.ch/bel2nanopub/RAljxBRWrFMDlVSGrRPx4AAwk1X6KowagjpSKjlGBKQGk#assertion http://www.tkuhn.ch/bel2nanopub/RAljxBRWrFMDlVSGrRPx4AAwk1X6KowagjpSKjlGBKQGk#_1 http://purl.obolibrary.org/obo/RO_0002204 http://www.informatics.jax.org/marker/MGI:99605 http://www.tkuhn.ch/bel2nanopub/RAljxBRWrFMDlVSGrRPx4AAwk1X6KowagjpSKjlGBKQGk#_1 http://www.w3.org/1999/02/22-rdf-syntax-ns#type http://www.ebi.ac.uk/chebi/searchId.do?chebiId=CHEBI_33697 http://www.tkuhn.ch/bel2nanopub/RAljxBRWrFMDlVSGrRPx4AAwk1X6KowagjpSKjlGBKQGk#_2 http://purl.obolibrary.org/obo/BFO_0000066 http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?id=10090 http://www.tkuhn.ch/bel2nanopub/RAljxBRWrFMDlVSGrRPx4AAwk1X6KowagjpSKjlGBKQGk#_2 http://www.w3.org/1999/02/22-rdf-syntax-ns#object http://www.tkuhn.ch/bel2nanopub/RAljxBRWrFMDlVSGrRPx4AAwk1X6KowagjpSKjlGBKQGk#_1 http://www.tkuhn.ch/bel2nanopub/RAljxBRWrFMDlVSGrRPx4AAwk1X6KowagjpSKjlGBKQGk#_2 http://www.w3.org/1999/02/22-rdf-syntax-ns#predicate http://www.selventa.com/vocabulary/increases http://www.tkuhn.ch/bel2nanopub/RAljxBRWrFMDlVSGrRPx4AAwk1X6KowagjpSKjlGBKQGk#_2 http://www.w3.org/1999/02/22-rdf-syntax-ns#subject http://www.ebi.ac.uk/chebi/searchId.do?chebiId=6494 http://www.tkuhn.ch/bel2nanopub/RAljxBRWrFMDlVSGrRPx4AAwk1X6KowagjpSKjlGBKQGk#_2 http://www.w3.org/1999/02/22-rdf-syntax-ns#type http://www.w3.org/1999/02/22-rdf-syntax-ns#Statement http://www.tkuhn.ch/bel2nanopub/RAljxBRWrFMDlVSGrRPx4AAwk1X6KowagjpSKjlGBKQGk#assertion http://www.w3.org/2000/01/rdf-schema#label a(CHEBI:lipopolysaccharide) -> r(MGI:Cntfr) http://www.tkuhn.ch/bel2nanopub/RAljxBRWrFMDlVSGrRPx4AAwk1X6KowagjpSKjlGBKQGk#provenance http://resource.belframework.org/belframework/1.0/knowledge/large_corpus.bel http://purl.org/dc/elements/1.1/description Approximately 61,000 statements. http://resource.belframework.org/belframework/1.0/knowledge/large_corpus.bel http://purl.org/dc/elements/1.1/rights Copyright (c) 2011-2012, Selventa. All rights reserved. http://resource.belframework.org/belframework/1.0/knowledge/large_corpus.bel http://purl.org/dc/elements/1.1/title BEL Framework Large Corpus Document http://resource.belframework.org/belframework/1.0/knowledge/large_corpus.bel http://purl.org/pav/authoredBy http://www.tkuhn.ch/bel2nanopub/RAljxBRWrFMDlVSGrRPx4AAwk1X6KowagjpSKjlGBKQGk#_4 http://resource.belframework.org/belframework/1.0/knowledge/large_corpus.bel http://purl.org/pav/version 1.4 http://www.tkuhn.ch/bel2nanopub/RAljxBRWrFMDlVSGrRPx4AAwk1X6KowagjpSKjlGBKQGk#_3 http://www.w3.org/ns/prov#value In the rat pineal gland, prominent expression of serine protease inhibitor 3 (SPI-3) mRNA is seen after systemic injection of lipopolysaccharide. The up-regulation of SPI-3 mRNA expression is also confirmed by northern blotting. Most SPI-3 mRNA-positive cells simultaneously express synaptophysin, a marker for pinealocytes, but not glial fibrillary acidic protein, a marker for astrocytes. This indicates that SPI-3 mRNA-positive cells are pinealocytes. Almost all SPI-3 mRNA-positive cells also showed translocation of the signal transducers and activators of transcription 3 (STAT3) into nuclei after lipopolysaccharide injection. These data support previous in vitro results that SPI-3 expression is induced in a STAT3-mediated manner. In addition, the expression of ciliary neurotrophic factor receptor (CNTFR) and leukemia inhibitory factor receptor (LIFR) mRNAs, but not of interleukin 6 receptor mRNA, was up-regulated after systemic lipopolysaccharide treatment. Because these receptors are upstream of STAT3, the present results suggest that cytokines such as LIF and/or CNTF induce SPI-3 expression via STAT3 in the pineal gland in response to inflammatory stimulus. We conclude that although the functional consequences of SPI-3 in the pineal gland during systemic inflammation are unknown, SPI-3 may have a crucial role in preventing some degenerative proteolysis induced by inflammatory stimuli. http://www.tkuhn.ch/bel2nanopub/RAljxBRWrFMDlVSGrRPx4AAwk1X6KowagjpSKjlGBKQGk#_3 http://www.w3.org/ns/prov#wasQuotedFrom http://www.ncbi.nlm.nih.gov/pubmed/12127095 http://www.tkuhn.ch/bel2nanopub/RAljxBRWrFMDlVSGrRPx4AAwk1X6KowagjpSKjlGBKQGk#_4 http://www.w3.org/2000/01/rdf-schema#label Selventa http://www.tkuhn.ch/bel2nanopub/RAljxBRWrFMDlVSGrRPx4AAwk1X6KowagjpSKjlGBKQGk#assertion http://www.w3.org/ns/prov#hadPrimarySource http://www.ncbi.nlm.nih.gov/pubmed/12127095 http://www.tkuhn.ch/bel2nanopub/RAljxBRWrFMDlVSGrRPx4AAwk1X6KowagjpSKjlGBKQGk#assertion http://www.w3.org/ns/prov#wasDerivedFrom http://resource.belframework.org/belframework/1.0/knowledge/large_corpus.bel http://www.tkuhn.ch/bel2nanopub/RAljxBRWrFMDlVSGrRPx4AAwk1X6KowagjpSKjlGBKQGk#assertion http://www.w3.org/ns/prov#wasDerivedFrom http://www.tkuhn.ch/bel2nanopub/RAljxBRWrFMDlVSGrRPx4AAwk1X6KowagjpSKjlGBKQGk#_3 http://www.tkuhn.ch/bel2nanopub/RAljxBRWrFMDlVSGrRPx4AAwk1X6KowagjpSKjlGBKQGk#pubinfo http://www.tkuhn.ch/bel2nanopub/RAljxBRWrFMDlVSGrRPx4AAwk1X6KowagjpSKjlGBKQGk http://purl.org/dc/terms/created 2014-07-03T14:30:04.490+02:00 http://www.tkuhn.ch/bel2nanopub/RAljxBRWrFMDlVSGrRPx4AAwk1X6KowagjpSKjlGBKQGk http://purl.org/pav/createdBy http://orcid.org/0000-0001-6818-334X http://www.tkuhn.ch/bel2nanopub/RAljxBRWrFMDlVSGrRPx4AAwk1X6KowagjpSKjlGBKQGk http://purl.org/pav/createdBy http://orcid.org/0000-0002-1267-0234