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All rights reserved. http://resource.belframework.org/belframework/1.0/knowledge/large_corpus.bel http://purl.org/dc/elements/1.1/title BEL Framework Large Corpus Document http://resource.belframework.org/belframework/1.0/knowledge/large_corpus.bel http://purl.org/pav/authoredBy http://www.tkuhn.ch/bel2nanopub/RAmDhNNP_Jou0fGkB8sAg2_RJ9BRKnxDKratWAO5YHDes#_6 http://resource.belframework.org/belframework/1.0/knowledge/large_corpus.bel http://purl.org/pav/version 1.4 http://www.tkuhn.ch/bel2nanopub/RAmDhNNP_Jou0fGkB8sAg2_RJ9BRKnxDKratWAO5YHDes#_5 http://www.w3.org/ns/prov#value On exposure of the cells to TGFbeta1, S100C/A11 was phosphorylated, bound to nucleolin, and transferred to the nucleus, resulting in induction of p21WAF1/CIP1 and p15INK4B through activation of Sp1. Protein kinase C alpha (PKCalpha) was shown to phosphorylate 10Thr of S100C/A11, which is a critical event for the signal transduction. The TGFbeta1-induced growth inhibition was almost completely mitigated when PKCalpha activity was blocked or when S100C/A11 was functionally sequestered. http://www.tkuhn.ch/bel2nanopub/RAmDhNNP_Jou0fGkB8sAg2_RJ9BRKnxDKratWAO5YHDes#_5 http://www.w3.org/ns/prov#wasQuotedFrom http://www.ncbi.nlm.nih.gov/pubmed/15051732 http://www.tkuhn.ch/bel2nanopub/RAmDhNNP_Jou0fGkB8sAg2_RJ9BRKnxDKratWAO5YHDes#_6 http://www.w3.org/2000/01/rdf-schema#label Selventa http://www.tkuhn.ch/bel2nanopub/RAmDhNNP_Jou0fGkB8sAg2_RJ9BRKnxDKratWAO5YHDes#assertion http://www.w3.org/ns/prov#hadPrimarySource http://www.ncbi.nlm.nih.gov/pubmed/15051732 http://www.tkuhn.ch/bel2nanopub/RAmDhNNP_Jou0fGkB8sAg2_RJ9BRKnxDKratWAO5YHDes#assertion http://www.w3.org/ns/prov#wasDerivedFrom http://resource.belframework.org/belframework/1.0/knowledge/large_corpus.bel http://www.tkuhn.ch/bel2nanopub/RAmDhNNP_Jou0fGkB8sAg2_RJ9BRKnxDKratWAO5YHDes#assertion http://www.w3.org/ns/prov#wasDerivedFrom http://www.tkuhn.ch/bel2nanopub/RAmDhNNP_Jou0fGkB8sAg2_RJ9BRKnxDKratWAO5YHDes#_5 http://www.tkuhn.ch/bel2nanopub/RAmDhNNP_Jou0fGkB8sAg2_RJ9BRKnxDKratWAO5YHDes#pubinfo http://www.tkuhn.ch/bel2nanopub/RAmDhNNP_Jou0fGkB8sAg2_RJ9BRKnxDKratWAO5YHDes http://purl.org/dc/terms/created 2014-07-03T14:30:22.151+02:00 http://www.tkuhn.ch/bel2nanopub/RAmDhNNP_Jou0fGkB8sAg2_RJ9BRKnxDKratWAO5YHDes http://purl.org/pav/createdBy http://orcid.org/0000-0001-6818-334X http://www.tkuhn.ch/bel2nanopub/RAmDhNNP_Jou0fGkB8sAg2_RJ9BRKnxDKratWAO5YHDes http://purl.org/pav/createdBy http://orcid.org/0000-0002-1267-0234