. . . . . . . . . . . . . . . . . . "a(CHEBI:\"sodium nitroprusside\") -| (cat(p(RGD:Cyp2e1)) => a(SCHEM:\"6-Hydroxychlorzoxazone\"))" . "cat(p(RGD:Cyp2e1)) => a(SCHEM:\"6-Hydroxychlorzoxazone\")" . "Approximately 61,000 statements." . "Copyright (c) 2011-2012, Selventa. All rights reserved." . "BEL Framework Large Corpus Document" . . "1.4" . "The rapid and direct effects of nitric oxide (NO) donors sodium nitroprusside (SNP) and isosorbide dinitrate (ISDN) on the hepatic and biliary disposition of chlorzoxazone (CZX), a marker of CYP2E1, and dextromethorphan (DEM), a marker of CYP2D1, were studied in a single-pass isolated perfused rat liver model. Both ISDN and SNP significantly reduced (30 and 60%, respectively) the hepatic extraction ratio of CZX and decreased (50 and 70%, respectively) the recovery of the CYP2E1-mediated metabolite, 6-hydroxychlorzoxazone, in the outlet perfusate and bile." . . "Selventa" . . . . "2014-07-03T14:30:42.730+02:00"^^ . . .