sub:provenance {
  beldoc: dce:description "Approximately 61,000 statements." ;
    dce:rights "Copyright (c) 2011-2012, Selventa. All rights reserved." ;
    dce:title "BEL Framework Large Corpus Document" ;
    pav:authoredBy sub:_4 ;
    pav:version "1.4" .
  sub:_3 prov:value "Indeed, the proportion of cardiac output that goes to adipose tissue is decreased in obesity, and the obese do not show the post-prandial increase in blood flow which occurs in lean individuals (Karpe et al. 2002). Activation of a transcription factor, hypoxia inducible factor-1 (HIF-1), through the stimulation of the expression of the HIF-1a subunit - the molecular sensor of hypoxia (Semenza 2001, Wenger 2002, Hopfl et al. 2004) - may be the mechanism through which low oxygen tension links to inflammation (Trayhurn & Wood 2004). The target genes for HIF-1 include VEGF and leptin, and expression of both of these has been shown to be stimulated in 3T3-L1 adipocytes in response to hypoxia (Lolmede et al. 2003)." ;
    prov:wasQuotedFrom pubmed:16026420 .
  sub:_4 rdfs:label "Selventa" .
  sub:assertion prov:hadPrimarySource pubmed:16026420 ;
    prov:wasDerivedFrom beldoc: , sub:_3 .
}