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All rights reserved. http://resource.belframework.org/belframework/1.0/knowledge/large_corpus.bel http://purl.org/dc/elements/1.1/title BEL Framework Large Corpus Document http://resource.belframework.org/belframework/1.0/knowledge/large_corpus.bel http://purl.org/pav/authoredBy http://www.tkuhn.ch/bel2nanopub/RAmgYSknQTf_KBbmAv-muB6BAghHg9kEKtWA0BCBl_7qQ#_5 http://resource.belframework.org/belframework/1.0/knowledge/large_corpus.bel http://purl.org/pav/version 1.4 http://www.tkuhn.ch/bel2nanopub/RAmgYSknQTf_KBbmAv-muB6BAghHg9kEKtWA0BCBl_7qQ#_4 http://www.w3.org/ns/prov#value Autocrine pathways were blocked with suramin, a general inhibitor of growth factor receptor binding, and resulted in more than a 10-fold increase in lysyl oxidase expression and proenzyme production. This regulation was found to be reversible and occurred at the transcriptional level determined using lysyl oxidase promoter/reporter gene assays. from NCI NCI04 A polysulphonated naphthylurea with potential antineoplastic activity. Suramin blocks the binding of various growth factors, including insulin-like growth factor I (IGF-I), epidermal growth factor (EGF), platelet-derived growth factor (PDGF), and tumor growth factor-beta (TGF-beta), to their receptors, thereby inhibiting endothelial cell proliferation and migration. This agent also inhibits vascular endothelial growth factor (VEGF)- and basic fibroblast growth factor (bFGF)-induced angiogenesis; retroviral reverse transcriptase; uncoupling of G-proteins from receptors; topoisomerases; cellular folate transport; and Steroidogenesis.(NCI04) http://www.tkuhn.ch/bel2nanopub/RAmgYSknQTf_KBbmAv-muB6BAghHg9kEKtWA0BCBl_7qQ#_4 http://www.w3.org/ns/prov#wasQuotedFrom http://www.ncbi.nlm.nih.gov/pubmed/12788924 http://www.tkuhn.ch/bel2nanopub/RAmgYSknQTf_KBbmAv-muB6BAghHg9kEKtWA0BCBl_7qQ#_5 http://www.w3.org/2000/01/rdf-schema#label Selventa http://www.tkuhn.ch/bel2nanopub/RAmgYSknQTf_KBbmAv-muB6BAghHg9kEKtWA0BCBl_7qQ#assertion http://www.w3.org/ns/prov#hadPrimarySource http://www.ncbi.nlm.nih.gov/pubmed/12788924 http://www.tkuhn.ch/bel2nanopub/RAmgYSknQTf_KBbmAv-muB6BAghHg9kEKtWA0BCBl_7qQ#assertion http://www.w3.org/ns/prov#wasDerivedFrom http://resource.belframework.org/belframework/1.0/knowledge/large_corpus.bel http://www.tkuhn.ch/bel2nanopub/RAmgYSknQTf_KBbmAv-muB6BAghHg9kEKtWA0BCBl_7qQ#assertion http://www.w3.org/ns/prov#wasDerivedFrom http://www.tkuhn.ch/bel2nanopub/RAmgYSknQTf_KBbmAv-muB6BAghHg9kEKtWA0BCBl_7qQ#_4 http://www.tkuhn.ch/bel2nanopub/RAmgYSknQTf_KBbmAv-muB6BAghHg9kEKtWA0BCBl_7qQ#pubinfo http://www.tkuhn.ch/bel2nanopub/RAmgYSknQTf_KBbmAv-muB6BAghHg9kEKtWA0BCBl_7qQ http://purl.org/dc/terms/created 2014-07-03T14:30:13.254+02:00 http://www.tkuhn.ch/bel2nanopub/RAmgYSknQTf_KBbmAv-muB6BAghHg9kEKtWA0BCBl_7qQ http://purl.org/pav/createdBy http://orcid.org/0000-0001-6818-334X http://www.tkuhn.ch/bel2nanopub/RAmgYSknQTf_KBbmAv-muB6BAghHg9kEKtWA0BCBl_7qQ http://purl.org/pav/createdBy http://orcid.org/0000-0002-1267-0234