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All rights reserved. http://resource.belframework.org/belframework/1.0/knowledge/large_corpus.bel http://purl.org/dc/elements/1.1/title BEL Framework Large Corpus Document http://resource.belframework.org/belframework/1.0/knowledge/large_corpus.bel http://purl.org/pav/authoredBy http://www.tkuhn.ch/bel2nanopub/RAmqB7rxs6bt1hmhmdfxvkytXWPEViGkztWk7FIEbpReU#_6 http://resource.belframework.org/belframework/1.0/knowledge/large_corpus.bel http://purl.org/pav/version 1.4 http://www.tkuhn.ch/bel2nanopub/RAmqB7rxs6bt1hmhmdfxvkytXWPEViGkztWk7FIEbpReU#_5 http://www.w3.org/ns/prov#value Ariadne: Thus, the major components of the AP-1 in MEK-DD-transformed CEFs were shown to be Fra-2 and c-Jun, and Fra-2 was highly phosphorylated, as reported in CEFs transformed by v- src , Ha- ras , and activated raf (17 , 22) . [Regulation] Here, we report that the transcriptional activity of Fra-2/c-Jun heterodimer was greatly enhanced by cotransfecting a constitutively active mutant of MEK1 gene (MEK-DD) into F9 cells, indicating that Fra-2 was converted into an active transactivator after phosphorylation by MAPK. http://www.tkuhn.ch/bel2nanopub/RAmqB7rxs6bt1hmhmdfxvkytXWPEViGkztWk7FIEbpReU#_5 http://www.w3.org/ns/prov#wasQuotedFrom http://www.ncbi.nlm.nih.gov/pubmed/10359014 http://www.tkuhn.ch/bel2nanopub/RAmqB7rxs6bt1hmhmdfxvkytXWPEViGkztWk7FIEbpReU#_6 http://www.w3.org/2000/01/rdf-schema#label Selventa http://www.tkuhn.ch/bel2nanopub/RAmqB7rxs6bt1hmhmdfxvkytXWPEViGkztWk7FIEbpReU#assertion http://www.w3.org/ns/prov#hadPrimarySource http://www.ncbi.nlm.nih.gov/pubmed/10359014 http://www.tkuhn.ch/bel2nanopub/RAmqB7rxs6bt1hmhmdfxvkytXWPEViGkztWk7FIEbpReU#assertion http://www.w3.org/ns/prov#wasDerivedFrom http://resource.belframework.org/belframework/1.0/knowledge/large_corpus.bel http://www.tkuhn.ch/bel2nanopub/RAmqB7rxs6bt1hmhmdfxvkytXWPEViGkztWk7FIEbpReU#assertion http://www.w3.org/ns/prov#wasDerivedFrom http://www.tkuhn.ch/bel2nanopub/RAmqB7rxs6bt1hmhmdfxvkytXWPEViGkztWk7FIEbpReU#_5 http://www.tkuhn.ch/bel2nanopub/RAmqB7rxs6bt1hmhmdfxvkytXWPEViGkztWk7FIEbpReU#pubinfo http://www.tkuhn.ch/bel2nanopub/RAmqB7rxs6bt1hmhmdfxvkytXWPEViGkztWk7FIEbpReU http://purl.org/dc/terms/created 2014-07-03T14:29:47.298+02:00 http://www.tkuhn.ch/bel2nanopub/RAmqB7rxs6bt1hmhmdfxvkytXWPEViGkztWk7FIEbpReU http://purl.org/pav/createdBy http://orcid.org/0000-0001-6818-334X http://www.tkuhn.ch/bel2nanopub/RAmqB7rxs6bt1hmhmdfxvkytXWPEViGkztWk7FIEbpReU http://purl.org/pav/createdBy http://orcid.org/0000-0002-1267-0234