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All rights reserved. http://resource.belframework.org/belframework/1.0/knowledge/large_corpus.bel http://purl.org/dc/elements/1.1/title BEL Framework Large Corpus Document http://resource.belframework.org/belframework/1.0/knowledge/large_corpus.bel http://purl.org/pav/authoredBy http://www.tkuhn.ch/bel2nanopub/RAmqlxXT_n3EmJoA1ZDyG_xLeYO8ZFKosn8JOweGPLydA#_6 http://resource.belframework.org/belframework/1.0/knowledge/large_corpus.bel http://purl.org/pav/version 1.4 http://www.tkuhn.ch/bel2nanopub/RAmqlxXT_n3EmJoA1ZDyG_xLeYO8ZFKosn8JOweGPLydA#_5 http://www.w3.org/ns/prov#value MafB/Kreisler is induced in response to ERK and synergizes with GATA and Ets to enhance transcription from the proximal promoter. The requirement for MafB in promoter regulation is demonstrated by inhibition of transactivation following dominant-negative or antisense suppression of MafB function. Thus, ERK promotes megakaryocyte differentiation by coordinate regulation of nuclear factors that synergize in GPIIb promoter regulation. These results establish a novel role for MafB as a regulator of ERK-induced gene expression. http://www.tkuhn.ch/bel2nanopub/RAmqlxXT_n3EmJoA1ZDyG_xLeYO8ZFKosn8JOweGPLydA#_5 http://www.w3.org/ns/prov#wasQuotedFrom http://www.ncbi.nlm.nih.gov/pubmed/15121870 http://www.tkuhn.ch/bel2nanopub/RAmqlxXT_n3EmJoA1ZDyG_xLeYO8ZFKosn8JOweGPLydA#_6 http://www.w3.org/2000/01/rdf-schema#label Selventa http://www.tkuhn.ch/bel2nanopub/RAmqlxXT_n3EmJoA1ZDyG_xLeYO8ZFKosn8JOweGPLydA#assertion http://www.w3.org/ns/prov#hadPrimarySource http://www.ncbi.nlm.nih.gov/pubmed/15121870 http://www.tkuhn.ch/bel2nanopub/RAmqlxXT_n3EmJoA1ZDyG_xLeYO8ZFKosn8JOweGPLydA#assertion http://www.w3.org/ns/prov#wasDerivedFrom http://resource.belframework.org/belframework/1.0/knowledge/large_corpus.bel http://www.tkuhn.ch/bel2nanopub/RAmqlxXT_n3EmJoA1ZDyG_xLeYO8ZFKosn8JOweGPLydA#assertion http://www.w3.org/ns/prov#wasDerivedFrom http://www.tkuhn.ch/bel2nanopub/RAmqlxXT_n3EmJoA1ZDyG_xLeYO8ZFKosn8JOweGPLydA#_5 http://www.tkuhn.ch/bel2nanopub/RAmqlxXT_n3EmJoA1ZDyG_xLeYO8ZFKosn8JOweGPLydA#pubinfo http://www.tkuhn.ch/bel2nanopub/RAmqlxXT_n3EmJoA1ZDyG_xLeYO8ZFKosn8JOweGPLydA http://purl.org/dc/terms/created 2014-07-03T14:30:23.095+02:00 http://www.tkuhn.ch/bel2nanopub/RAmqlxXT_n3EmJoA1ZDyG_xLeYO8ZFKosn8JOweGPLydA http://purl.org/pav/createdBy http://orcid.org/0000-0001-6818-334X http://www.tkuhn.ch/bel2nanopub/RAmqlxXT_n3EmJoA1ZDyG_xLeYO8ZFKosn8JOweGPLydA http://purl.org/pav/createdBy http://orcid.org/0000-0002-1267-0234