@prefix dc: <http://purl.org/dc/terms/> .
@prefix this: <http://www.tkuhn.ch/bel2nanopub/RAn08SNQIwZH30Hg_KrwO9oEFhbYVBiBuEt5unqd-UKf0> .
@prefix sub: <http://www.tkuhn.ch/bel2nanopub/RAn08SNQIwZH30Hg_KrwO9oEFhbYVBiBuEt5unqd-UKf0#> .
@prefix beldoc: <http://resource.belframework.org/belframework/20131211/knowledge/small_corpus.bel> .
@prefix rdfs: <http://www.w3.org/2000/01/rdf-schema#> .
@prefix rdf: <http://www.w3.org/1999/02/22-rdf-syntax-ns#> .
@prefix xsd: <http://www.w3.org/2001/XMLSchema#> .
@prefix dce: <http://purl.org/dc/elements/1.1/> .
@prefix pav: <http://purl.org/pav/> .
@prefix np: <http://www.nanopub.org/nschema#> .
@prefix belv: <http://www.selventa.com/vocabulary/> .
@prefix prov: <http://www.w3.org/ns/prov#> .
@prefix go: <http://amigo.geneontology.org/amigo/term/GO:> .
@prefix Protein: <http://www.ebi.ac.uk/chebi/searchId.do?chebiId=CHEBI_36080> .
@prefix mgi: <http://www.informatics.jax.org/marker/MGI:> .
@prefix geneProductOf: <http://purl.obolibrary.org/obo/RO_0002204> .
@prefix hasAgent: <http://semanticscience.org/resource/SIO_000139> .
@prefix RNA: <http://www.ebi.ac.uk/chebi/searchId.do?chebiId=CHEBI_33697> .
@prefix hasAnnotation: <http://semanticscience.org/resource/SIO_000255> .
@prefix species: <http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?id=> .
@prefix occursIn: <http://purl.obolibrary.org/obo/BFO_0000066> .
@prefix obo: <http://purl.obolibrary.org/obo/> .
@prefix pubmed: <http://www.ncbi.nlm.nih.gov/pubmed/> .
@prefix orcid: <http://orcid.org/> .

sub:Head {
  this: np:hasAssertion sub:assertion;
    np:hasProvenance sub:provenance;
    np:hasPublicationInfo sub:pubinfo;
    a np:Nanopublication .
}

sub:assertion {
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  sub:_4 occursIn: obo:UBERON_0002048, species:10090;
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    rdf:object sub:_3;
    rdf:predicate belv:directlyIncreases;
    rdf:subject sub:_1;
    a rdf:Statement .
  
  sub:_5 dc:subject "TextLocation";
    rdf:value "Results" .
  
  sub:assertion rdfs:label "tscript(p(MGI:Ctnnb1)) => r(MGI:Mycn)" .
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sub:provenance {
  beldoc: dce:description "Approximately 2000 hand curated statements drawn from 57 PubMeds.";
    dce:rights "Copyright (c) 2011-2012, Selventa. All Rights Reserved.";
    dce:title "BEL Framework Small Corpus Document";
    dc:license "Creative Commons Attribution-Non-Commercial-ShareAlike 3.0 Unported License";
    pav:authoredBy sub:_7;
    pav:version "20131211" .
  
  sub:_6 prov:value """Co-transfection of luciferase reporter plasmids containing these sequences along with
expression plasmids encoding either an activated β-catenin containing mutations
in the GSK-3h phosphorylation sites (β-catenin/4145) or with a TCF3-VP16 fusion
protein demonstrated that both promoter sequences could be activated by transcriptional
mediators of Wnt signaling (Figs. 7A and B). Addition of both h-catenin/4154
and TCF3-VP16 resulted in cooperative activation of both promoters (Figs.
7A and B). Furthermore, a dominantnegative TCF3 construct repressed both BMP4
and N-myc promoters (Figs. 7C and D). Chromatin immunoprecipitation assays show
that β-catenin associates with the conserved LEF/TCF DNA binding sites located
in the BMP4 and N-myc promoters, indicating direct regulation of these promoters
by canonical Wnt signaling (Figs. 7E and F). Together, these results demonstrate
that BMP4 and Nmyc are targets of Wnt/β-catenin signaling in lung airway epithelium.""";
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  sub:_7 rdfs:comment "support@belframework.org";
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  sub:assertion prov:hadPrimarySource pubmed:15907834;
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sub:pubinfo {
  this: dc:created "2014-07-03T14:31:16.859+02:00"^^xsd:dateTime;
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