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All rights reserved. http://resource.belframework.org/belframework/1.0/knowledge/large_corpus.bel http://purl.org/dc/elements/1.1/title BEL Framework Large Corpus Document http://resource.belframework.org/belframework/1.0/knowledge/large_corpus.bel http://purl.org/pav/authoredBy http://www.tkuhn.ch/bel2nanopub/RAn592mfP44ODhqFfMYZRlPeXE_R4GH9g7aL1rZhq1ScA#_6 http://resource.belframework.org/belframework/1.0/knowledge/large_corpus.bel http://purl.org/pav/version 1.4 http://www.tkuhn.ch/bel2nanopub/RAn592mfP44ODhqFfMYZRlPeXE_R4GH9g7aL1rZhq1ScA#_5 http://www.w3.org/ns/prov#value Using mass spectrometry, we identified Ser(24) in the pleckstrin homology (PH) domain of IRS-1 as a specific phosphorylation site for mPLK. IRS-1 mutants S24D or S24E (mimicking phosphorylation at Ser(24)) had impaired ability to associate with insulin receptors resulting in diminished tyrosine phosphorylation of IRS-1 and impaired ability of IRS-1 to bind and activate PI-3 kinase in response to insulin. Wild-type mPLK, but not a kinase-inactive mutant (mPLK-KD), directly phosphorylated full-length IRS-1 in vitro. This in vitro phosphorylation was increased when mPLK was immunoprecipitated from tumor necrosis factor (TNF)-alpha-treated cells. http://www.tkuhn.ch/bel2nanopub/RAn592mfP44ODhqFfMYZRlPeXE_R4GH9g7aL1rZhq1ScA#_5 http://www.w3.org/ns/prov#wasQuotedFrom http://www.ncbi.nlm.nih.gov/pubmed/15849359 http://www.tkuhn.ch/bel2nanopub/RAn592mfP44ODhqFfMYZRlPeXE_R4GH9g7aL1rZhq1ScA#_6 http://www.w3.org/2000/01/rdf-schema#label Selventa http://www.tkuhn.ch/bel2nanopub/RAn592mfP44ODhqFfMYZRlPeXE_R4GH9g7aL1rZhq1ScA#assertion http://www.w3.org/ns/prov#hadPrimarySource http://www.ncbi.nlm.nih.gov/pubmed/15849359 http://www.tkuhn.ch/bel2nanopub/RAn592mfP44ODhqFfMYZRlPeXE_R4GH9g7aL1rZhq1ScA#assertion http://www.w3.org/ns/prov#wasDerivedFrom http://resource.belframework.org/belframework/1.0/knowledge/large_corpus.bel http://www.tkuhn.ch/bel2nanopub/RAn592mfP44ODhqFfMYZRlPeXE_R4GH9g7aL1rZhq1ScA#assertion http://www.w3.org/ns/prov#wasDerivedFrom http://www.tkuhn.ch/bel2nanopub/RAn592mfP44ODhqFfMYZRlPeXE_R4GH9g7aL1rZhq1ScA#_5 http://www.tkuhn.ch/bel2nanopub/RAn592mfP44ODhqFfMYZRlPeXE_R4GH9g7aL1rZhq1ScA#pubinfo http://www.tkuhn.ch/bel2nanopub/RAn592mfP44ODhqFfMYZRlPeXE_R4GH9g7aL1rZhq1ScA http://purl.org/dc/terms/created 2014-07-03T14:30:34.683+02:00 http://www.tkuhn.ch/bel2nanopub/RAn592mfP44ODhqFfMYZRlPeXE_R4GH9g7aL1rZhq1ScA http://purl.org/pav/createdBy http://orcid.org/0000-0001-6818-334X http://www.tkuhn.ch/bel2nanopub/RAn592mfP44ODhqFfMYZRlPeXE_R4GH9g7aL1rZhq1ScA http://purl.org/pav/createdBy http://orcid.org/0000-0002-1267-0234