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All rights reserved. http://resource.belframework.org/belframework/1.0/knowledge/large_corpus.bel http://purl.org/dc/elements/1.1/title BEL Framework Large Corpus Document http://resource.belframework.org/belframework/1.0/knowledge/large_corpus.bel http://purl.org/pav/authoredBy http://www.tkuhn.ch/bel2nanopub/RAnCXia5f4kUxWPcaI7j1nYNdVP9qj0PpDhPI1dGCjMv8#_6 http://resource.belframework.org/belframework/1.0/knowledge/large_corpus.bel http://purl.org/pav/version 1.4 http://www.tkuhn.ch/bel2nanopub/RAnCXia5f4kUxWPcaI7j1nYNdVP9qj0PpDhPI1dGCjMv8#_5 http://www.w3.org/ns/prov#value Here we show that EphB stimulates a metalloproteinase cleavage of ephrinB2, producing a carboxy-terminal fragment that is further processed by PS1/gamma-secretase to produce intracellular peptide ephrinB2/CTF2. This peptide binds Src and inhibits its association with inhibitory kinase Csk, allowing autophosphorylation of Src at residue tyr418. http://www.tkuhn.ch/bel2nanopub/RAnCXia5f4kUxWPcaI7j1nYNdVP9qj0PpDhPI1dGCjMv8#_5 http://www.w3.org/ns/prov#wasQuotedFrom http://www.ncbi.nlm.nih.gov/pubmed/16511561 http://www.tkuhn.ch/bel2nanopub/RAnCXia5f4kUxWPcaI7j1nYNdVP9qj0PpDhPI1dGCjMv8#_6 http://www.w3.org/2000/01/rdf-schema#label Selventa http://www.tkuhn.ch/bel2nanopub/RAnCXia5f4kUxWPcaI7j1nYNdVP9qj0PpDhPI1dGCjMv8#assertion http://www.w3.org/ns/prov#hadPrimarySource http://www.ncbi.nlm.nih.gov/pubmed/16511561 http://www.tkuhn.ch/bel2nanopub/RAnCXia5f4kUxWPcaI7j1nYNdVP9qj0PpDhPI1dGCjMv8#assertion http://www.w3.org/ns/prov#wasDerivedFrom http://resource.belframework.org/belframework/1.0/knowledge/large_corpus.bel http://www.tkuhn.ch/bel2nanopub/RAnCXia5f4kUxWPcaI7j1nYNdVP9qj0PpDhPI1dGCjMv8#assertion http://www.w3.org/ns/prov#wasDerivedFrom http://www.tkuhn.ch/bel2nanopub/RAnCXia5f4kUxWPcaI7j1nYNdVP9qj0PpDhPI1dGCjMv8#_5 http://www.tkuhn.ch/bel2nanopub/RAnCXia5f4kUxWPcaI7j1nYNdVP9qj0PpDhPI1dGCjMv8#pubinfo http://www.tkuhn.ch/bel2nanopub/RAnCXia5f4kUxWPcaI7j1nYNdVP9qj0PpDhPI1dGCjMv8 http://purl.org/dc/terms/created 2014-07-03T14:30:41.827+02:00 http://www.tkuhn.ch/bel2nanopub/RAnCXia5f4kUxWPcaI7j1nYNdVP9qj0PpDhPI1dGCjMv8 http://purl.org/pav/createdBy http://orcid.org/0000-0001-6818-334X http://www.tkuhn.ch/bel2nanopub/RAnCXia5f4kUxWPcaI7j1nYNdVP9qj0PpDhPI1dGCjMv8 http://purl.org/pav/createdBy http://orcid.org/0000-0002-1267-0234