. . . . . . . . . . . "a(SCHEM:\"D-Glucose, anhydrous\") -| path(SDIS:\"muscle insulin receptor signaling pathway\")" . "Approximately 61,000 statements." . "Copyright (c) 2011-2012, Selventa. All rights reserved." . "BEL Framework Large Corpus Document" . . "1.4" . "Protein kinase C (PKC) is a serine kinase that has a number of potential substrates, including the insulin receptor (152). PKC is activated by the intracellular metabolite diacylglycerol (DAG), the concentration of which increases in a glucose-dependent manner during exposure of isolated muscles to hyperinsulinemia (153). In NIH3T3 cells overexpressing the insulin receptor, insulin desensitization by glucose can be blocked by PKC inhibitors and thiazolidinediones (154)." . . "Selventa" . . . . "2014-07-03T14:29:46.610+02:00"^^ . . .