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Review
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gtp(p(SFAM:"RHO Family")) -> kin(p(HGNC:PKN1))
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Approximately 2000 hand curated statements drawn from 57 PubMeds.
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Copyright (c) 2011-2012, Selventa. All Rights Reserved.
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BEL Framework Small Corpus Document
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Creative Commons Attribution-Non-Commercial-ShareAlike 3.0 Unported License
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The Rho family of small GTPases, consisting of Rho, Rac, and cyclin-dependent kinase
(Cdc) 42, regulate cytoskeletal organization during the cell cycle and also
mediate Ras-induced activation of Raf, especially C-Raf.134-136 These GTPases do
not directly bind to Raf but, instead, signal by activating downstream kinases.
Rho signals by activating the serine/threonine protein kinases N1 and N2 and Rho-associated
kinase 1, whereas Rac and Cdc42 signal through p21-activated kinase
(PAK).134-136
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support@belframework.org
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Selventa
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2014-07-03T14:31:15.650+02:00
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