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All rights reserved. http://resource.belframework.org/belframework/1.0/knowledge/large_corpus.bel http://purl.org/dc/elements/1.1/title BEL Framework Large Corpus Document http://resource.belframework.org/belframework/1.0/knowledge/large_corpus.bel http://purl.org/pav/authoredBy http://www.tkuhn.ch/bel2nanopub/RAnY_lLtR2B74Jz1X8L1s21Vr1TR6fPchMVlHMp5sN1EQ#_4 http://resource.belframework.org/belframework/1.0/knowledge/large_corpus.bel http://purl.org/pav/version 1.4 http://www.tkuhn.ch/bel2nanopub/RAnY_lLtR2B74Jz1X8L1s21Vr1TR6fPchMVlHMp5sN1EQ#_3 http://www.w3.org/ns/prov#value Inhibition of PI3-kinase activity using a dominant negative mutant (30), or pharmacological agents such as wortmannin or LY294002 (31), abolishes insulin stimulated glucose uptake and inhibits GLUT4 vesicle translocation to the plasma membrane. Many other cellular effects of insulin, such as antilipolysis, activation of fatty acid synthesis, acetyl CoA-carboxylase, glycogen synthase, Akt phosphorylation, glycogen synthase kinase 3b inactivation, and stimulation of protein synthesis and DNA synthesis, are also inhibited by PI3- kinase suppression PIP3, rather than PIP2, is the major mediator of PI3- kinase dependent biological actions of insulin http://www.tkuhn.ch/bel2nanopub/RAnY_lLtR2B74Jz1X8L1s21Vr1TR6fPchMVlHMp5sN1EQ#_3 http://www.w3.org/ns/prov#wasQuotedFrom http://www.ncbi.nlm.nih.gov/pubmed/10194465 http://www.tkuhn.ch/bel2nanopub/RAnY_lLtR2B74Jz1X8L1s21Vr1TR6fPchMVlHMp5sN1EQ#_4 http://www.w3.org/2000/01/rdf-schema#label Selventa http://www.tkuhn.ch/bel2nanopub/RAnY_lLtR2B74Jz1X8L1s21Vr1TR6fPchMVlHMp5sN1EQ#assertion http://www.w3.org/ns/prov#hadPrimarySource http://www.ncbi.nlm.nih.gov/pubmed/10194465 http://www.tkuhn.ch/bel2nanopub/RAnY_lLtR2B74Jz1X8L1s21Vr1TR6fPchMVlHMp5sN1EQ#assertion http://www.w3.org/ns/prov#wasDerivedFrom http://resource.belframework.org/belframework/1.0/knowledge/large_corpus.bel http://www.tkuhn.ch/bel2nanopub/RAnY_lLtR2B74Jz1X8L1s21Vr1TR6fPchMVlHMp5sN1EQ#assertion http://www.w3.org/ns/prov#wasDerivedFrom http://www.tkuhn.ch/bel2nanopub/RAnY_lLtR2B74Jz1X8L1s21Vr1TR6fPchMVlHMp5sN1EQ#_3 http://www.tkuhn.ch/bel2nanopub/RAnY_lLtR2B74Jz1X8L1s21Vr1TR6fPchMVlHMp5sN1EQ#pubinfo http://www.tkuhn.ch/bel2nanopub/RAnY_lLtR2B74Jz1X8L1s21Vr1TR6fPchMVlHMp5sN1EQ http://purl.org/dc/terms/created 2014-07-03T14:29:46.502+02:00 http://www.tkuhn.ch/bel2nanopub/RAnY_lLtR2B74Jz1X8L1s21Vr1TR6fPchMVlHMp5sN1EQ http://purl.org/pav/createdBy http://orcid.org/0000-0001-6818-334X http://www.tkuhn.ch/bel2nanopub/RAnY_lLtR2B74Jz1X8L1s21Vr1TR6fPchMVlHMp5sN1EQ http://purl.org/pav/createdBy http://orcid.org/0000-0002-1267-0234