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[Human immunodeficiency virus type 1 (HIV-1) infection frequently causes neurologic disease, which is the result of viral replication and activation of macrophages and microglia in the CNS, and subsequent secretion of high levels of neurotoxic products, including tumor necrosis factor-? (TNF-?).]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.
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